ENSMUSG00000049672


Mus musculus

Features
Gene ID: ENSMUSG00000049672
  
Biological name :Zbtb14
  
Synonyms : Q08376 / Zbtb14 / zinc finger and BTB domain containing 14
  
Possible biological names infered from orthology : O43829
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E1.3
Gene start: 69383050
Gene end: 69390750
  
Corresponding Affymetrix probe sets: 10446581 (MoGene1.0st)   1420864_at (Mouse Genome 430 2.0 Array)   1420865_at (Mouse Genome 430 2.0 Array)   1420866_at (Mouse Genome 430 2.0 Array)   1437585_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054897
Ensembl peptide - ENSMUSP00000108294
Ensembl peptide - ENSMUSP00000108296
NCBI entrez gene - 22666     See in Manteia.
MGI - MGI:1195345
RefSeq - XM_011246424
RefSeq - NM_001356282
RefSeq - NM_001356283
RefSeq - NM_009547
RefSeq - XM_006524212
RefSeq Peptide - NP_033573
RefSeq Peptide - NP_001343211
RefSeq Peptide - NP_001343212
swissprot - Q08376
swissprot - Q544H8
Ensembl - ENSMUSG00000049672
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zbtb14ENSDARG00000098273Danio rerio
 ZBTB14ENSGALG00000038340Gallus gallus
 O43829ENSG00000198081Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zbtb38 / zinc finger and BTB domain containing 38 / Q8NAP3*ENSMUSG0000004043327
Zbtb21 / zinc finger and BTB domain containing 21 / Q9ULJ3*ENSMUSG0000004696225
Q8BN78 / Zbtb33 / zinc finger and BTB domain containing 33 / Q86T24*ENSMUSG0000004804722
Zbtb4 / Q5F293 / zinc finger and BTB domain containing 4 / Q9P1Z0*ENSMUSG0000001875020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0003170 heart valve development IMP
 biological_processGO:0003279 cardiac septum development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IBA
 biological_processGO:0060976 coronary vasculature development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016235 aggresome ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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