ENSMUSG00000050063


Mus musculus

Features
Gene ID: ENSMUSG00000050063
  
Biological name :Klk6
  
Synonyms : kallikrein related peptidase 6 / Klk6
  
Possible biological names infered from orthology : Q92876
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 43824499
Gene end: 43832030
  
Corresponding Affymetrix probe sets: 10552516 (MoGene1.0st)   1448982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103600
Ensembl peptide - ENSMUSP00000103601
Ensembl peptide - ENSMUSP00000103602
Ensembl peptide - ENSMUSP00000135591
NCBI entrez gene - 19144     See in Manteia.
MGI - MGI:1343166
RefSeq - NM_001164697
RefSeq - NM_001164696
RefSeq - NM_001164698
RefSeq - NM_011177
RefSeq Peptide - NP_001158168
RefSeq Peptide - NP_001158169
RefSeq Peptide - NP_001158170
RefSeq Peptide - NP_035307
swissprot - Q91Y82
swissprot - H3BKZ6
Ensembl - ENSMUSG00000050063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLK6ENSG00000167755Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klk8 / Q61955 / Kallikrein-8 / O60259* / kallikrein related peptidase 8*ENSMUSG0000006402343
Klk13 / kallikrein related-peptidase 13 / Q9UKR3*ENSMUSG0000005404643
Klk14 / Q8CGR5 / Kallikrein-14 / Q9P0G3* / kallikrein related peptidase 14*ENSMUSG0000004473742
Klk11 / Q9QYN3 / Kallikrein-11 / Q9UBX7* / kallikrein related peptidase 11*ENSMUSG0000006761642
Klk15 / kallikrein related peptidase 15 / Q9H2R5*ENSMUSG0000005519341
Try10 / trypsin 10 / PRSS3* / PRSS1* / PRSS2* / P35030* / P07478* / P07477* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000007152141
Prss1 / PRSS2* / PRSS3* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000006275141
Prss2 / P07146 / protease, serine 2 / PRSS1* / PRSS3* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000005716340
Try5 / PRSS2* / PRSS3* / PRSS1* / P07477* / P35030* / P07478* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000003693840
Try4 / trypsin 4 / PRSS3* / PRSS1* / PRSS2* / P35030* / P07478* / P07477* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000005410640
Gm10334 / PRSS1* / PRSS2* / PRSS3* / P07477* / P07478* / P35030* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000007151740
Prss3 / PRSS2* / PRSS1* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000007151940
Gm5771 / PRSS1* / PRSS2* / PRSS3* / P07477* / P07478* / P35030* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000005811940
1810009J06Rik / RIKEN cDNA 1810009J06 geneENSMUSG0000009480839
Gm2663ENSMUSG0000009652539
Klk9 / Q9UKQ9* / AC011473.4* / kallikrein related peptidase 9*ENSMUSG0000004788438
2210010C04Rik / RIKEN cDNA 2210010C04 geneENSMUSG0000002988238
Gm4744ENSMUSG0000006325225


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway ISO
 biological_processGO:0070997 neuron death ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0030141 secretory granule IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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