ENSMUSG00000044737


Mus musculus

Features
Gene ID: ENSMUSG00000044737
  
Biological name :Klk14
  
Synonyms : Kallikrein-14 / Klk14 / Q8CGR5
  
Possible biological names infered from orthology : kallikrein related peptidase 14 / Q9P0G3
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 43690418
Gene end: 43695536
  
Corresponding Affymetrix probe sets: 10552462 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000056935
NCBI entrez gene - 317653     See in Manteia.
MGI - MGI:2447564
RefSeq - XM_006540956
RefSeq - NM_174866
RefSeq - XM_006540955
RefSeq Peptide - NP_777355
swissprot - Q8CGR5
swissprot - A0A0B6VSR0
Ensembl - ENSMUSG00000044737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLK14ENSG00000129437Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm10334 / PRSS1* / PRSS2* / PRSS3* / P07477* / P07478* / P35030* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000007151747
Prss2 / P07146 / protease, serine 2 / PRSS1* / PRSS3* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000005716347
Prss3 / PRSS2* / PRSS1* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000007151947
Try10 / trypsin 10 / PRSS3* / PRSS1* / PRSS2* / P35030* / P07478* / P07477* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000007152146
Gm2663ENSMUSG0000009652546
Gm5771 / PRSS1* / PRSS2* / PRSS3* / P07477* / P07478* / P35030* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000005811946
Klk13 / kallikrein related-peptidase 13 / Q9UKR3*ENSMUSG0000005404646
1810009J06Rik / RIKEN cDNA 1810009J06 geneENSMUSG0000009480846
Klk8 / Q61955 / Kallikrein-8 / O60259* / kallikrein related peptidase 8*ENSMUSG0000006402346
Try4 / trypsin 4 / PRSS3* / PRSS1* / PRSS2* / P35030* / P07478* / P07477* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000005410646
Prss1 / PRSS2* / PRSS3* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000006275146
Try5 / PRSS2* / PRSS3* / PRSS1* / P07477* / P35030* / P07478* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000003693846
Klk9 / Q9UKQ9* / AC011473.4* / kallikrein related peptidase 9*ENSMUSG0000004788445
Klk15 / kallikrein related peptidase 15 / Q9H2R5*ENSMUSG0000005519345
2210010C04Rik / RIKEN cDNA 2210010C04 geneENSMUSG0000002988245
Klk11 / Q9QYN3 / Kallikrein-11 / Q9UBX7* / kallikrein related peptidase 11*ENSMUSG0000006761643
Klk6 / kallikrein related peptidase 6 / Q92876*ENSMUSG0000005006342
Gm4744ENSMUSG0000006325231


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0009566 fertilization ISS
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway ISS
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway ISS
 biological_processGO:0048730 epidermis morphogenesis ISS
 biological_processGO:0070684 seminal clot liquefaction ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055095 Q8BT20 / Spink6 / serine peptidase inhibitor, Kazal type 6 / Q6UWN8*  / complex / reaction






 

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