ENSMUSG00000050556


Mus musculus

Features
Gene ID: ENSMUSG00000050556
  
Biological name :Kcnb1
  
Synonyms : Kcnb1 / Potassium voltage-gated channel subfamily B member 1 / Q03717
  
Possible biological names infered from orthology : Q14721
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 167095969
Gene end: 167190155
  
Corresponding Affymetrix probe sets: 10489872 (MoGene1.0st)   1423179_at (Mouse Genome 430 2.0 Array)   1423180_at (Mouse Genome 430 2.0 Array)   1440838_at (Mouse Genome 430 2.0 Array)   1458270_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057981
Ensembl peptide - ENSMUSP00000147093
NCBI entrez gene - 16500     See in Manteia.
MGI - MGI:96666
RefSeq - XM_017315733
RefSeq - NM_008420
RefSeq - XM_017315732
RefSeq Peptide - NP_032446
swissprot - Q03717
Ensembl - ENSMUSG00000050556
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnb1ENSDARG00000060095Danio rerio
 KCNB1ENSGALG00000004758Gallus gallus
 KCNB1ENSG00000158445Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnb2 / A6H8H5 / Potassium voltage-gated channel subfamily B member 2 / Q92953*ENSMUSG0000009208364
Kcnv1 / Q8BZN2 / Potassium voltage-gated channel subfamily V member 1 / Q6PIU1* / potassium voltage-gated channel modifier subfamily V member 1*ENSMUSG0000002234225
Kcns3 / Q8BQZ8 / Potassium voltage-gated channel subfamily S member 3 / Q9BQ31* / potassium voltage-gated channel modifier subfamily S member 3*ENSMUSG0000004367325
Kcnf1 / potassium voltage-gated channel modifier subfamily F member 1 / Q9H3M0*ENSMUSG0000005172622
Kcns2 / O35174 / Potassium voltage-gated channel subfamily S member 2 / Q9ULS6* / potassium voltage-gated channel modifier subfamily S member 2*ENSMUSG0000005096322
Kcng1 / A2BDX4 / Potassium voltage-gated channel subfamily G member 1 / Q9UIX4* / potassium voltage-gated channel modifier subfamily G member 1*ENSMUSG0000007457522
Kcns1 / O35173 / Potassium voltage-gated channel subfamily S member 1 / Q96KK3* / potassium voltage-gated channel modifier subfamily S member 1*ENSMUSG0000004016421
Kcnv2 / Q8CFS6 / Potassium voltage-gated channel subfamily V member 2 / Q8TDN2* / potassium voltage-gated channel modifier subfamily V member 2*ENSMUSG0000004729821
Kcng4 / Q80XM3 / Potassium voltage-gated channel subfamily G member 4 / Q8TDN1* / potassium voltage-gated channel modifier subfamily G member 4*ENSMUSG0000004524621
Kcng2 / potassium voltage-gated channel modifier subfamily G member 2 / Q9UJ96*ENSMUSG0000005985219
Kcng3 / P59053 / Potassium voltage-gated channel subfamily G member 3 / Q8TAE7* / potassium voltage-gated channel modifier subfamily G member 3*ENSMUSG0000004505318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR003968  Potassium channel, voltage dependent, Kv
 IPR003973  Potassium channel, voltage dependent, Kv2
 IPR004350  Potassium channel, voltage dependent, Kv2.1
 IPR005821  Ion transport domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential ISS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport ISO
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis ISS
 biological_processGO:0007215 glutamate receptor signaling pathway ISS
 biological_processGO:0010701 positive regulation of norepinephrine secretion ISS
 biological_processGO:0031669 cellular response to nutrient levels ISS
 biological_processGO:0033605 positive regulation of catecholamine secretion ISS
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis ISS
 biological_processGO:0046676 negative regulation of insulin secretion IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 biological_processGO:0072659 protein localization to plasma membrane ISS
 biological_processGO:0090314 positive regulation of protein targeting to membrane ISO
 biological_processGO:0098900 regulation of action potential IMP
 biological_processGO:1900454 positive regulation of long term synaptic depression IMP
 biological_processGO:2000671 regulation of motor neuron apoptotic process ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0032809 neuronal cell body membrane ISS
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity ISO
 molecular_functionGO:0005251 delayed rectifier potassium channel activity ISO
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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