ENSMUSG00000050737


Mus musculus

Features
Gene ID: ENSMUSG00000050737
  
Biological name :Ptges
  
Synonyms : Prostaglandin E synthase / Ptges / Q9JM51
  
Possible biological names infered from orthology : O14684
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 30889471
Gene end: 30929863
  
Corresponding Affymetrix probe sets: 10481518 (MoGene1.0st)   1439747_at (Mouse Genome 430 2.0 Array)   1449449_at (Mouse Genome 430 2.0 Array)   1449450_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099916
NCBI entrez gene - 64292     See in Manteia.
MGI - MGI:1927593
RefSeq - NM_022415
RefSeq Peptide - NP_071860
swissprot - Q9JM51
Ensembl - ENSMUSG00000050737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgesENSDARG00000020136Danio rerio
 PTGESENSGALG00000038013Gallus gallus
 PTGESENSG00000148344Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mgst1 / Q91VS7 / Microsomal glutathione S-transferase 1 / P10620*ENSMUSG0000000854036


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process ISO
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0051592 response to calcium ion IEA
 cellular_componentGO:0005641 nuclear envelope lumen IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004667 prostaglandin-D synthase activity TAS
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0043295 glutathione binding IEA
 molecular_functionGO:0050220 prostaglandin-E synthase activity ISO


Pathways (from Reactome)
Pathway description
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0009811 abnormal prostaglandin level "anomaly in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009817 decreased leukotriene level "reduced concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
Show

Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000050737 Ptges / Q9JM51 / Prostaglandin E synthase / O14684*  / complex






 

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