ENSMUSG00000051910


Mus musculus

Features
Gene ID: ENSMUSG00000051910
  
Biological name :Sox6
  
Synonyms : P40645 / Sox6 / SRY (sex determining region Y)-box 6
  
Possible biological names infered from orthology : P35712 / SRY-box 6
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F1
Gene start: 115470872
Gene end: 116038796
  
Corresponding Affymetrix probe sets: 10567108 (MoGene1.0st)   1426018_a_at (Mouse Genome 430 2.0 Array)   1427677_a_at (Mouse Genome 430 2.0 Array)   1434918_at (Mouse Genome 430 2.0 Array)   1447655_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145561
Ensembl peptide - ENSMUSP00000129512
Ensembl peptide - ENSMUSP00000145576
Ensembl peptide - ENSMUSP00000145931
Ensembl peptide - ENSMUSP00000145919
Ensembl peptide - ENSMUSP00000145732
Ensembl peptide - ENSMUSP00000072583
Ensembl peptide - ENSMUSP00000102223
Ensembl peptide - ENSMUSP00000126404
Ensembl peptide - ENSMUSP00000129027
NCBI entrez gene - 20679     See in Manteia.
MGI - MGI:98368
RefSeq - XM_017322071
RefSeq - XM_011241705
RefSeq - XM_011241706
RefSeq - XM_011241707
RefSeq - XM_011241708
RefSeq - XM_011241709
RefSeq - XM_011241710
RefSeq - XM_011241711
RefSeq - XM_011241712
RefSeq - XM_011241713
RefSeq - XM_011241714
RefSeq - XM_011241715
RefSeq - XM_017322068
RefSeq - XM_017322069
RefSeq - XM_017322070
RefSeq - NM_001025559
RefSeq - NM_001025560
RefSeq - NM_001277326
RefSeq - NM_001277327
RefSeq - NM_001277328
RefSeq - NM_011445
RefSeq - XM_006507494
RefSeq - XM_006507495
RefSeq - XM_006507496
RefSeq - XM_006507497
RefSeq - XM_006507498
RefSeq - XM_006507499
RefSeq - XM_006507500
RefSeq - XM_006507501
RefSeq - XM_006507504
RefSeq - XM_006507514
RefSeq Peptide - NP_001264257
RefSeq Peptide - NP_035575
RefSeq Peptide - NP_001020730
RefSeq Peptide - NP_001020731
RefSeq Peptide - NP_001264255
RefSeq Peptide - NP_001264256
swissprot - Q8BSS6
swissprot - A0A0U1RNH0
swissprot - Q3V1J7
swissprot - A0A0U1RPC1
swissprot - A0A0U1RNW8
swissprot - A0A0U1RNI3
swissprot - P40645
swissprot - E9PUW0
Ensembl - ENSMUSG00000051910
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox6ENSDARG00000015536Danio rerio
 SOX6ENSGALG00000006074Gallus gallus
 SOX6ENSG00000110693Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox5 / P35710 / SRY (sex determining region Y)-box 5 / P35711* / SRY-box 5*ENSMUSG0000004154056
Sox13 / Q04891 / Transcription factor SOX-13 / Q9UN79* / SRY-box 13*ENSMUSG0000007064331
Sox30 / Q8CGW4 / Transcription factor SOX-30 / O94993* / SRY-box 30*ENSMUSG0000004048914


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR027153  Transcription factor SOX-6
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016458 gene silencing IMP
 biological_processGO:0021778 oligodendrocyte cell fate specification IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IDA
 biological_processGO:0042692 muscle cell differentiation IDA
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048708 astrocyte differentiation IEA
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0051216 cartilage development IGI
 biological_processGO:0055007 cardiac muscle cell differentiation IDA
 biological_processGO:0061036 positive regulation of cartilage development ISO
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus ISO
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation ISO
 biological_processGO:2000741 positive regulation of mesenchymal stem cell differentiation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IC
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002898 absent cartilage "absence of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Sox5tm2Vlf/Sox5tm2Vlf,Sox6tm2.1Vlf/Sox6tm2.1Vlf,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Mt1-HGFSF)19Lmb/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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