ENSMUSG00000052105


Mus musculus

Features
Gene ID: ENSMUSG00000052105
  
Biological name :Mtcl1
  
Synonyms : Microtubule cross-linking factor 1 / Mtcl1 / Q3UHU5
  
Possible biological names infered from orthology : microtubule crosslinking factor 1 / Q9Y4B5
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.1
Gene start: 66336982
Gene end: 66449750
  
Corresponding Affymetrix probe sets: 10452538 (MoGene1.0st)   1429053_at (Mouse Genome 430 2.0 Array)   1442363_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083899
Ensembl peptide - ENSMUSP00000094894
Ensembl peptide - ENSMUSP00000121387
Ensembl peptide - ENSMUSP00000135690
NCBI entrez gene - 68617     See in Manteia.
MGI - MGI:1915867
RefSeq - XM_017317622
RefSeq - XM_006524851
RefSeq - XM_006524852
RefSeq - XM_006524853
RefSeq - XM_006524856
RefSeq - XM_011246587
RefSeq - NM_001114098
RefSeq - NM_172963
RefSeq - XM_006524849
RefSeq Peptide - NP_001107570
RefSeq Peptide - NP_766551
swissprot - H3BL83
swissprot - Q3UHU5
swissprot - B8JJI7
Ensembl - ENSMUSG00000052105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtcl1ENSDARG00000091408Danio rerio
 MTCL1ENSGALG00000038316Gallus gallus
 MTCL1ENSG00000168502Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Soga1 / suppressor of glucose, autophagy associated 1 / O94964*ENSMUSG0000005548532
Soga3 / Q6NZL0 / Protein SOGA3 / Q5TF21* / AL096711.2* / SOGA family member 3*ENSMUSG0000003891621
AC153912.1ENSMUSG000001107231


Protein motifs (from Interpro)
Interpro ID Name
 IPR027881  Protein SOGA
 IPR027882  Domain of unknown function DUF4482


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010506 regulation of autophagy IEA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030496 midbody ISO
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

Allelic Composition: Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

Allelic Composition: Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

Allelic Composition: Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

Allelic Composition: Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl

 MP:0010047 axonal spheroids "focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

Allelic Composition: Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl

 MP:0010733 abnormal axon initial segment morphology "any structural anomaly of the short unmyelinated axon segment adjacent to the cell soma where voltage gated channels accumulate and axon potential initiation usually occurs" [PMID:18929652]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

Allelic Composition: Mtcl1tm1.1Atsuz/Mtcl1tm1.1Atsuz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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