ENSMUSG00000052428


Mus musculus

Features
Gene ID: ENSMUSG00000052428
  
Biological name :Tmco1
  
Synonyms : Calcium load-activated calcium channel / Q921L3 / Tmco1
  
Possible biological names infered from orthology : Q9UM00 / transmembrane and coiled-coil domains 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.3
Gene start: 167308378
Gene end: 167333978
  
Corresponding Affymetrix probe sets: 10351404 (MoGene1.0st)   1423759_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141241
Ensembl peptide - ENSMUSP00000142042
Ensembl peptide - ENSMUSP00000141373
Ensembl peptide - ENSMUSP00000095081
NCBI entrez gene - 68944     See in Manteia.
MGI - MGI:1921173
RefSeq - NM_001039483
RefSeq Peptide - NP_001034572
swissprot - A0A0A6YW31
swissprot - A0A0A6YVS2
swissprot - Q921L3
Ensembl - ENSMUSG00000052428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmco1ENSDARG00000069099Danio rerio
 TMCO1ENSGALG00000033460Gallus gallus
 TMCO1ENSG00000143183Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002809  Integral membrane protein EMC3/TMCO1-like
 IPR008559  Calcium load-activated calcium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006983 ER overload response ISS
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IMP
 biological_processGO:0070588 calcium ion transmembrane transport ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISS
 molecular_functionGO:0005262 calcium channel activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0004380 short frontal bone "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0012175 flat face "the appearance of a flattened surface outline or contour of a normally rounded face of an organism" [MGI:anna]
Show

Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
Show

Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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