ENSMUSG00000053441


Mus musculus

Features
Gene ID: ENSMUSG00000053441
  
Biological name :Adamts19
  
Synonyms : Adamts19 / A disintegrin and metalloproteinase with thrombospondin motifs 19 / P59509
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 19 / Q8TE59
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: D3
Gene start: 58836764
Gene end: 59053678
  
Corresponding Affymetrix probe sets: 10455919 (MoGene1.0st)   1442459_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050535
NCBI entrez gene - 240322     See in Manteia.
MGI - MGI:2442875
RefSeq - XM_011246926
RefSeq - NM_175506
RefSeq - XM_006525920
RefSeq - XM_006525921
RefSeq - XM_006525919
RefSeq Peptide - NP_780715
swissprot - P59509
Ensembl - ENSMUSG00000053441
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADAMTS19ENSGALG00000000151Gallus gallus
 Q8TE59ENSG00000145808Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adamts17 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17 / Q8TE56* / ADAM metallopeptidase with thrombospondin type 1 motif 17*ENSMUSG0000005814552
Q811B3 / Adamts12 / A disintegrin and metalloproteinase with thrombospondin motifs 12 / P58397* / ADAM metallopeptidase with thrombospondin type 1 motif 12*ENSMUSG0000004749732
Q4VC17 / Adamts18 / A disintegrin and metalloproteinase with thrombospondin motifs 18 / Q8TE60* / ADAM metallopeptidase with thrombospondin type 1 motif 18*ENSMUSG0000005339930
Q68SA9 / Adamts7 / A disintegrin and metalloproteinase with thrombospondin motifs 7 / Q9UKP4* / ADAM metallopeptidase with thrombospondin type 1 motif 7*ENSMUSG0000003236330
Adamts6 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 / Q9UKP5* / ADAM metallopeptidase with thrombospondin type 1 motif 6*ENSMUSG0000004616930
Q69Z28 / Adamts16 / A disintegrin and metalloproteinase with thrombospondin motifs 16 / Q8TE57* / ADAM metallopeptidase with thrombospondin type 1 motif 16*ENSMUSG0000004953829
P58459 / Adamts10 / Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 (Adamts10), transcript variant 4, mRNA. / Q9H324* / ADAM meta...ENSMUSG0000002429928
Adamts14 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 / Q8WXS8* / ADAM metallopeptidase with thrombospondin type 1 motif 14*ENSMUSG0000005990125
Q8C9W3 / Adamts2 / A disintegrin and metalloproteinase with thrombospondin motifs 2 / O95450* / ADAM metallopeptidase with thrombospondin type 1 motif 2*ENSMUSG0000003654525
Adamts3 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 / O15072* / ADAM metallopeptidase with thrombospondin type 1 motif 3*ENSMUSG0000004363524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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