ENSMUSG00000032363


Mus musculus

Features
Gene ID: ENSMUSG00000032363
  
Biological name :Adamts7
  
Synonyms : Adamts7 / A disintegrin and metalloproteinase with thrombospondin motifs 7 / Q68SA9
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 7 / Q9UKP4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.1
Gene start: 90163069
Gene end: 90208071
  
Corresponding Affymetrix probe sets: 10587748 (MoGene1.0st)   1452339_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108682
Ensembl peptide - ENSMUSP00000115972
Ensembl peptide - ENSMUSP00000119744
Ensembl peptide - ENSMUSP00000129292
Ensembl peptide - ENSMUSP00000108683
NCBI entrez gene - 108153     See in Manteia.
MGI - MGI:1347346
RefSeq - XM_006510764
RefSeq - NM_001003911
RefSeq - NM_001311115
RefSeq - NM_001326294
RefSeq - NM_001326351
RefSeq - XM_006510759
RefSeq - XM_006510760
RefSeq - XM_006510762
RefSeq Peptide - NP_001003911
RefSeq Peptide - NP_001313223
RefSeq Peptide - NP_001313280
RefSeq Peptide - NP_001298044
swissprot - D6RI90
swissprot - F6UD05
swissprot - E9PX36
swissprot - Q68SA9
Ensembl - ENSMUSG00000032363
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX470176.1ENSDARG00000102478Danio rerio
 Q9UKP4ENSG00000136378Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q811B3 / Adamts12 / A disintegrin and metalloproteinase with thrombospondin motifs 12 / P58397* / ADAM metallopeptidase with thrombospondin type 1 motif 12*ENSMUSG0000004749742
Q4VC17 / Adamts18 / A disintegrin and metalloproteinase with thrombospondin motifs 18 / Q8TE60* / ADAM metallopeptidase with thrombospondin type 1 motif 18*ENSMUSG0000005339925
Adamts6 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 / Q9UKP5* / ADAM metallopeptidase with thrombospondin type 1 motif 6*ENSMUSG0000004616925
Q69Z28 / Adamts16 / A disintegrin and metalloproteinase with thrombospondin motifs 16 / Q8TE57* / ADAM metallopeptidase with thrombospondin type 1 motif 16*ENSMUSG0000004953825
P58459 / Adamts10 / Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 (Adamts10), transcript variant 4, mRNA. / Q9H324* / ADAM meta...ENSMUSG0000002429925
P59509 / Adamts19 / A disintegrin and metalloproteinase with thrombospondin motifs 19 / Q8TE59* / ADAM metallopeptidase with thrombospondin type 1 motif 19*ENSMUSG0000005344122
Adamts17 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17 / Q8TE56* / ADAM metallopeptidase with thrombospondin type 1 motif 17*ENSMUSG0000005814522
Q8C9W3 / Adamts2 / A disintegrin and metalloproteinase with thrombospondin motifs 2 / O95450* / ADAM metallopeptidase with thrombospondin type 1 motif 2*ENSMUSG0000003654521
Adamts3 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 / O15072* / ADAM metallopeptidase with thrombospondin type 1 motif 3*ENSMUSG0000004363520
Adamts14 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 / Q8WXS8* / ADAM metallopeptidase with thrombospondin type 1 motif 14*ENSMUSG0000005990119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation ISO
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process ISO
 biological_processGO:0071347 cellular response to interleukin-1 ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor ISO
 biological_processGO:0071773 cellular response to BMP stimulus ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0009986 cell surface IDA
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002309 abnormal vital capacity "anomaly in the amount of air that is exhaled by a maximal expiration following a maximal inspiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005585 increased tidal volume "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010042 abnormal oval cell physiology "any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
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Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0010896 decreased lung compliance "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010936 decreased airway resistance "reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010937 increased total lung capacity "greater volume of air contained in the lungs at the end of maximal inspiration" [MGI:csmith]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0020253 increased collagen level "increased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
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Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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