ENSG00000136378


Homo sapiens

Features
Gene ID: ENSG00000136378
  
Biological name :ADAMTS7
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 7 / ADAMTS7 / Q9UKP4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.1
Gene start: 78759203
Gene end: 78811431
  
Corresponding Affymetrix probe sets: 220705_s_at (Human Genome U133 Plus 2.0 Array)   220706_at (Human Genome U133 Plus 2.0 Array)   228911_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373472
NCBI entrez gene - 11173     See in Manteia.
OMIM - 605009
RefSeq - NM_014272
RefSeq - XM_005254137
RefSeq Peptide - NP_055087
swissprot - Q9UKP4
Ensembl - ENSG00000136378
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX470176.1ENSDARG00000102478Danio rerio
 Q68SA9ENSMUSG00000032363Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P58397 / ADAMTS12 / ADAM metallopeptidase with thrombospondin type 1 motif 12ENSG0000015138844
Q9UKP5 / ADAMTS6 / ADAM metallopeptidase with thrombospondin type 1 motif 6ENSG0000004919226
Q8TE57 / ADAMTS16 / ADAM metallopeptidase with thrombospondin type 1 motif 16ENSG0000014553625
Q9H324 / ADAMTS10 / ADAM metallopeptidase with thrombospondin type 1 motif 10ENSG0000014230325
Q8TE60 / ADAMTS18 / ADAM metallopeptidase with thrombospondin type 1 motif 18ENSG0000014087325
Q8TE56 / ADAMTS17 / ADAM metallopeptidase with thrombospondin type 1 motif 17ENSG0000014047022
Q8TE59 / ADAMTS19 / ADAM metallopeptidase with thrombospondin type 1 motif 19ENSG0000014580822
Q8WXS8 / ADAMTS14 / ADAM metallopeptidase with thrombospondin type 1 motif 14ENSG0000013831620
O95450 / ADAMTS2 / ADAM metallopeptidase with thrombospondin type 1 motif 2ENSG0000008711620
O15072 / ADAMTS3 / ADAM metallopeptidase with thrombospondin type 1 motif 3ENSG0000015614020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IDA
 biological_processGO:0036066 protein O-linked fucosylation TAS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IMP
 biological_processGO:0071347 cellular response to interleukin-1 IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:0071773 cellular response to BMP stimulus IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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