ENSG00000049192


Homo sapiens

Features
Gene ID: ENSG00000049192
  
Biological name :ADAMTS6
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 6 / ADAMTS6 / Q9UKP5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q12.3
Gene start: 65148736
Gene end: 65481920
  
Corresponding Affymetrix probe sets: 1570351_at (Human Genome U133 Plus 2.0 Array)   220866_at (Human Genome U133 Plus 2.0 Array)   237411_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370443
Ensembl peptide - ENSP00000424377
NCBI entrez gene - 11174     See in Manteia.
OMIM - 605008
RefSeq - XM_011543123
RefSeq - NM_197941
RefSeq - XM_011543121
RefSeq - XM_011543122
RefSeq - XM_011543113
RefSeq - XM_011543114
RefSeq - XM_011543115
RefSeq - XM_011543116
RefSeq - XM_011543117
RefSeq - XM_011543119
RefSeq - XM_011543120
RefSeq Peptide - NP_922932
swissprot - Q9UKP5
Ensembl - ENSG00000049192
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts6ENSDARG00000041982Danio rerio
 ADAMTS6ENSGALG00000014751Gallus gallus
 Adamts6ENSMUSG00000046169Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H324 / ADAMTS10 / ADAM metallopeptidase with thrombospondin type 1 motif 10ENSG0000014230360
Q9UKP4 / ADAMTS7 / ADAM metallopeptidase with thrombospondin type 1 motif 7ENSG0000013637840
Q8TE60 / ADAMTS18 / ADAM metallopeptidase with thrombospondin type 1 motif 18ENSG0000014087338
P58397 / ADAMTS12 / ADAM metallopeptidase with thrombospondin type 1 motif 12ENSG0000015138838
Q8TE57 / ADAMTS16 / ADAM metallopeptidase with thrombospondin type 1 motif 16ENSG0000014553636
Q8TE59 / ADAMTS19 / ADAM metallopeptidase with thrombospondin type 1 motif 19ENSG0000014580832
Q8TE56 / ADAMTS17 / ADAM metallopeptidase with thrombospondin type 1 motif 17ENSG0000014047031
O15072 / ADAMTS3 / ADAM metallopeptidase with thrombospondin type 1 motif 3ENSG0000015614030
O95450 / ADAMTS2 / ADAM metallopeptidase with thrombospondin type 1 motif 2ENSG0000008711629
Q8WXS8 / ADAMTS14 / ADAM metallopeptidase with thrombospondin type 1 motif 14ENSG0000013831629


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003279 cardiac septum development IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0060976 coronary vasculature development IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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