ENSG00000151388


Homo sapiens

Features
Gene ID: ENSG00000151388
  
Biological name :ADAMTS12
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 12 / ADAMTS12 / P58397
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p13.2
Gene start: 33523535
Gene end: 33892192
  
Corresponding Affymetrix probe sets: 221421_s_at (Human Genome U133 Plus 2.0 Array)   226997_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422554
Ensembl peptide - ENSP00000344847
Ensembl peptide - ENSP00000421638
NCBI entrez gene - 81792     See in Manteia.
OMIM - 606184
RefSeq - XM_017009907
RefSeq - NM_030955
RefSeq - XM_017009905
RefSeq - XM_017009906
RefSeq Peptide - NP_112217
swissprot - D6REX0
swissprot - P58397
Ensembl - ENSG00000151388
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts12ENSDARG00000067549Danio rerio
 Q811B3ENSMUSG00000047497Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UKP4 / ADAMTS7 / ADAM metallopeptidase with thrombospondin type 1 motif 7ENSG0000013637846
Q8TE60 / ADAMTS18 / ADAM metallopeptidase with thrombospondin type 1 motif 18ENSG0000014087327
Q9UKP5 / ADAMTS6 / ADAM metallopeptidase with thrombospondin type 1 motif 6ENSG0000004919227
Q8TE57 / ADAMTS16 / ADAM metallopeptidase with thrombospondin type 1 motif 16ENSG0000014553626
Q9H324 / ADAMTS10 / ADAM metallopeptidase with thrombospondin type 1 motif 10ENSG0000014230325
Q8TE59 / ADAMTS19 / ADAM metallopeptidase with thrombospondin type 1 motif 19ENSG0000014580824
Q8TE56 / ADAMTS17 / ADAM metallopeptidase with thrombospondin type 1 motif 17ENSG0000014047022
O95450 / ADAMTS2 / ADAM metallopeptidase with thrombospondin type 1 motif 2ENSG0000008711620
O15072 / ADAMTS3 / ADAM metallopeptidase with thrombospondin type 1 motif 3ENSG0000015614020
Q8WXS8 / ADAMTS14 / ADAM metallopeptidase with thrombospondin type 1 motif 14ENSG0000013831619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030167 proteoglycan catabolic process IDA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IDA
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IMP
 biological_processGO:0071347 cellular response to interleukin-1 IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:0071773 cellular response to BMP stimulus IDA
 biological_processGO:1901509 regulation of endothelial tube morphogenesis IDA
 biological_processGO:1902203 negative regulation of hepatocyte growth factor receptor signaling pathway IDA
 biological_processGO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus IDA
 biological_processGO:2001113 negative regulation of cellular response to hepatocyte growth factor stimulus IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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