ENSMUSG00000047497


Mus musculus

Features
Gene ID: ENSMUSG00000047497
  
Biological name :Adamts12
  
Synonyms : Adamts12 / A disintegrin and metalloproteinase with thrombospondin motifs 12 / Q811B3
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 12 / P58397
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 11064790
Gene end: 11349231
  
Corresponding Affymetrix probe sets: 10423109 (MoGene1.0st)   1439827_at (Mouse Genome 430 2.0 Array)   1446666_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057796
NCBI entrez gene - 239337     See in Manteia.
MGI - MGI:2146046
RefSeq - NM_175501
RefSeq Peptide - NP_780710
swissprot - Q811B3
Ensembl - ENSMUSG00000047497
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts12ENSDARG00000067549Danio rerio
 P58397ENSG00000151388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q68SA9 / Adamts7 / A disintegrin and metalloproteinase with thrombospondin motifs 7 / Q9UKP4* / ADAM metallopeptidase with thrombospondin type 1 motif 7*ENSMUSG0000003236344
Q4VC17 / Adamts18 / A disintegrin and metalloproteinase with thrombospondin motifs 18 / Q8TE60* / ADAM metallopeptidase with thrombospondin type 1 motif 18*ENSMUSG0000005339927
Adamts6 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 / Q9UKP5* / ADAM metallopeptidase with thrombospondin type 1 motif 6*ENSMUSG0000004616927
Q69Z28 / Adamts16 / A disintegrin and metalloproteinase with thrombospondin motifs 16 / Q8TE57* / ADAM metallopeptidase with thrombospondin type 1 motif 16*ENSMUSG0000004953826
P58459 / Adamts10 / Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 (Adamts10), transcript variant 4, mRNA. / Q9H324* / ADAM meta...ENSMUSG0000002429926
P59509 / Adamts19 / A disintegrin and metalloproteinase with thrombospondin motifs 19 / Q8TE59* / ADAM metallopeptidase with thrombospondin type 1 motif 19*ENSMUSG0000005344124
Adamts17 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17 / Q8TE56* / ADAM metallopeptidase with thrombospondin type 1 motif 17*ENSMUSG0000005814523
Q8C9W3 / Adamts2 / A disintegrin and metalloproteinase with thrombospondin motifs 2 / O95450* / ADAM metallopeptidase with thrombospondin type 1 motif 2*ENSMUSG0000003654520
Adamts3 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 / O15072* / ADAM metallopeptidase with thrombospondin type 1 motif 3*ENSMUSG0000004363519
Adamts14 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 / Q8WXS8* / ADAM metallopeptidase with thrombospondin type 1 motif 14*ENSMUSG0000005990119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030167 proteoglycan catabolic process IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:1901509 regulation of endothelial tube morphogenesis IEA
 biological_processGO:1902203 negative regulation of hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:2001113 negative regulation of cellular response to hepatocyte growth factor stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr