ENSMUSG00000046169


Mus musculus

Features
Gene ID: ENSMUSG00000046169
  
Biological name :Adamts6
  
Synonyms : Adamts6 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 6 / Q9UKP5
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D1
Gene start: 104287835
Gene end: 104496695
  
Corresponding Affymetrix probe sets: 10406982 (MoGene1.0st)   1437506_at (Mouse Genome 430 2.0 Array)   1457548_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153194
Ensembl peptide - ENSMUSP00000153665
Ensembl peptide - ENSMUSP00000153504
Ensembl peptide - ENSMUSP00000153431
Ensembl peptide - ENSMUSP00000153359
Ensembl peptide - ENSMUSP00000064570
Ensembl peptide - ENSMUSP00000152936
NCBI entrez gene - 108154     See in Manteia.
MGI - MGI:1347348
RefSeq - XM_017315355
RefSeq - NM_001081020
RefSeq - XM_006517516
RefSeq - XM_006517517
RefSeq - XM_011244611
RefSeq Peptide - NP_001074489
swissprot - A0A286YCZ1
swissprot - A0A286YCD8
swissprot - A0A286YEC9
swissprot - D3Z1A5
Ensembl - ENSMUSG00000046169
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts6ENSDARG00000041982Danio rerio
 ADAMTS6ENSGALG00000014751Gallus gallus
 Q9UKP5ENSG00000049192Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P58459 / Adamts10 / Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 (Adamts10), transcript variant 4, mRNA. / Q9H324* / ADAM meta...ENSMUSG0000002429959
Q811B3 / Adamts12 / A disintegrin and metalloproteinase with thrombospondin motifs 12 / P58397* / ADAM metallopeptidase with thrombospondin type 1 motif 12*ENSMUSG0000004749738
Q68SA9 / Adamts7 / A disintegrin and metalloproteinase with thrombospondin motifs 7 / Q9UKP4* / ADAM metallopeptidase with thrombospondin type 1 motif 7*ENSMUSG0000003236338
Q4VC17 / Adamts18 / A disintegrin and metalloproteinase with thrombospondin motifs 18 / Q8TE60* / ADAM metallopeptidase with thrombospondin type 1 motif 18*ENSMUSG0000005339938
Q69Z28 / Adamts16 / A disintegrin and metalloproteinase with thrombospondin motifs 16 / Q8TE57* / ADAM metallopeptidase with thrombospondin type 1 motif 16*ENSMUSG0000004953836
Adamts17 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17 / Q8TE56* / ADAM metallopeptidase with thrombospondin type 1 motif 17*ENSMUSG0000005814532
P59509 / Adamts19 / A disintegrin and metalloproteinase with thrombospondin motifs 19 / Q8TE59* / ADAM metallopeptidase with thrombospondin type 1 motif 19*ENSMUSG0000005344132
Q8C9W3 / Adamts2 / A disintegrin and metalloproteinase with thrombospondin motifs 2 / O95450* / ADAM metallopeptidase with thrombospondin type 1 motif 2*ENSMUSG0000003654529
Adamts14 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 / Q8WXS8* / ADAM metallopeptidase with thrombospondin type 1 motif 14*ENSMUSG0000005990129
Adamts3 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 / O15072* / ADAM metallopeptidase with thrombospondin type 1 motif 3*ENSMUSG0000004363529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR010909  PLAC
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003279 cardiac septum development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0035904 aorta development IMP
 biological_processGO:0060976 coronary vasculature development IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
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Allelic Composition: Plxnd1b2b1863Clo/Plxnd1b2b1863Clo
Genetic Background: C57BL/6J-Plxnd1b2b1863Clo

Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo
Genetic Background: C57BL/6J-Adamts6b2b2029Clo

Allelic Composition: Adamts6b2b2228Clo/Adamts6b2b2228Clo
Genetic Background: C57BL/6J-Adamts6b2b2228Clo

Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo

Allelic Composition: Adamts6b2b2187.1Clo/Adamts6b2b2187.1Clo
Genetic Background: C57BL/6J-Adamts6b2b2187.1Clo

Allelic Composition: Adamts6b2b2405Clo/Adamts6b2b2405Clo
Genetic Background: C57BL/6J-Adamts6b2b2405Clo

Allelic Composition: Adamts6b2b2407Clo/Adamts6b2b2407Clo
Genetic Background: C57BL/6J-Adamts6b2b2407Clo

Allelic Composition: Adamts6b2b2744Clo/Adamts6b2b2744Clo
Genetic Background: C57BL/6J-Adamts6b2b2744Clo

Allelic Composition: Adamts6b2b2966.2Clo/Adamts6b2b2966.2Clo
Genetic Background: C57BL/6J-Adamts6b2b2966.2Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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