ENSMUSG00000054162


Mus musculus

Features
Gene ID: ENSMUSG00000054162
  
Biological name :Spock3
  
Synonyms : Q8BKV0 / Spock3 / Testican-3
  
Possible biological names infered from orthology : Q9BQ16 / SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.1
Gene start: 62951009
Gene end: 63357103
  
Corresponding Affymetrix probe sets: 10572024 (MoGene1.0st)   1449979_a_at (Mouse Genome 430 2.0 Array)   1459834_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091192
Ensembl peptide - ENSMUSP00000112930
Ensembl peptide - ENSMUSP00000113683
Ensembl peptide - ENSMUSP00000113797
NCBI entrez gene - 72902     See in Manteia.
MGI - MGI:1920152
RefSeq - XM_006509518
RefSeq - NM_001252620
RefSeq - NM_001252621
RefSeq - NM_023689
RefSeq - XM_006509516
RefSeq - XM_006509517
RefSeq Peptide - NP_001239549
RefSeq Peptide - NP_001239550
RefSeq Peptide - NP_076178
swissprot - Q8BKV0
Ensembl - ENSMUSG00000054162
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spock3ENSDARG00000070266Danio rerio
 SPOCK3ENSGALG00000009568Gallus gallus
 Q9BQ16ENSG00000196104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spock1 / sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 / Q08629*ENSMUSG0000005622253
Q9ER58 / Spock2 / Testican-2 / Q92563* / SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2*ENSMUSG0000005829744


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR002350  Kazal domain
 IPR011992  EF-hand domain pair
 IPR019577  SPARC/Testican, calcium-binding domain
 IPR036058  Kazal domain superfamily
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity ISO
 biological_processGO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IDA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity ISO
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1Rha,Tg(Tek-Jam3)1Maal/0
Genetic Background: B6.Cg-Jam3tm1Rha Tg(Tek-Jam3)1Maal

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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