ENSMUSG00000056537


Mus musculus

Features
Gene ID: ENSMUSG00000056537
  
Biological name :Rlim
  
Synonyms : Mus musculus ring finger protein, LIM domain interacting (Rlim), transcript variant 2, mRNA. / Q9WTV7 / Rlim
  
Possible biological names infered from orthology : Q9NVW2 / ring finger protein, LIM domain interacting
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 103957163
Gene end: 103981284
  
Corresponding Affymetrix probe sets: 10606195 (MoGene1.0st)   1417250_at (Mouse Genome 430 2.0 Array)   1418730_at (Mouse Genome 430 2.0 Array)   1418731_at (Mouse Genome 430 2.0 Array)   1439403_x_at (Mouse Genome 430 2.0 Array)   1440850_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070662
Ensembl peptide - ENSMUSP00000112820
NCBI entrez gene - 19820     See in Manteia.
MGI - MGI:1342291
RefSeq - XM_011247552
RefSeq - NM_001358205
RefSeq - NM_011276
RefSeq - XM_006527920
RefSeq - XM_006527921
RefSeq - XM_011247551
RefSeq - XM_006527918
RefSeq - XM_006527919
RefSeq Peptide - NP_035406
RefSeq Peptide - NP_001345134
swissprot - Q9WTV7
Ensembl - ENSMUSG00000056537
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rlimENSDARG00000079306Danio rerio
 RLIMENSGALG00000007750Gallus gallus
 RLIMENSG00000131263Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rnf6 / Q9DBU5 / E3 ubiquitin-protein ligase RNF6 / Q9Y252* / ring finger protein 6*ENSMUSG0000002963444
Rnf38 / Q8BI21 / Mus musculus ring finger protein 38 (Rnf38), transcript variant 3, mRNA. / Q9H0F5* / ring finger protein 38*ENSMUSG0000003569614
Rnf44 / Q3UHJ8 / RING finger protein 44 / Q7L0R7*ENSMUSG0000003492813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IGI
 biological_processGO:0060816 random inactivation of X chromosome ISO
 biological_processGO:1900095 regulation of dosage compensation by inactivation of X chromosome IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rlimtm1.2Inba/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0010382 abnormal dosage compensation, by inactivation of X chromosome "anomaly in the process of compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex" [GO:0009048]
Show

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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