ENSMUSG00000059305


Mus musculus

Features
Gene ID: ENSMUSG00000059305
  
Biological name :Vpreb1
  
Synonyms : P13372 / pre-B lymphocyte gene 1 / Vpreb1
  
Possible biological names infered from orthology : P12018 / V-set pre-B cell surrogate light chain 1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 16868403
Gene end: 16869255
  
Corresponding Affymetrix probe sets: 10438064 (MoGene1.0st)   1422416_s_at (Mouse Genome 430 2.0 Array)   1449869_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074537
NCBI entrez gene - 22362     See in Manteia.
MGI - MGI:98936
RefSeq - NM_016982
RefSeq Peptide - NP_058678
swissprot - P13372
swissprot - Q545E0
Ensembl - ENSMUSG00000059305
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P12018ENSG00000169575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vpreb2 / P13373 / pre-B lymphocyte gene 2 / VPREB1* / P12018* / V-set pre-B cell surrogate light chain 1*ENSMUSG0000005928097
Iglv3 / IGLV4-60* / IGLV4-69* / A0A075B6H9* / A0A075B6I1* / immunoglobulin lambda variable 4-60* / immunoglobulin lambda variable 4-69*ENSMUSG0000007693935
Vpreb3 / pre-B lymphocyte gene 3 / Q9UKI3* / V-set pre-B cell surrogate light chain 3*ENSMUSG0000000090330


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IGI
 biological_processGO:0002377 immunoglobulin production IGI
 biological_processGO:0006955 immune response IPI
 biological_processGO:0008361 regulation of cell size IGI
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0042100 B cell proliferation IMP
 biological_processGO:0048872 homeostasis of number of cells IGI
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IPI
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nr3c1tm1Dage/Nr3c1+
Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm Vpreb2tm1Ilm

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm Vpreb2tm1Ilm

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm Vpreb2tm1Ilm

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0005020 abnormal late pro-B cell "anomalous structure, developoment, or number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm Vpreb2tm1Ilm

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm Vpreb2tm1Ilm

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm Vpreb2tm1Ilm

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm Vpreb2tm1Ilm

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm,Vpreb2tm1Ilm/Vpreb2tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm Vpreb2tm1Ilm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000903 Vpreb3 / pre-B lymphocyte gene 3 / Q9UKI3* / V-set pre-B cell surrogate light chain 3*  / complex / reaction
 ENSMUSG00000059305 P13372 / Vpreb1 / pre-B lymphocyte gene 1 / P12018* / V-set pre-B cell surrogate light chain 1*  / complex / reaction
 ENSMUSG00000075370 Igll1 / P20764 / Immunoglobulin lambda-like polypeptide 1 / IGLC3* / IGLC7* / IGLC2* / IGLL5* / IGLC1* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 1* / immunog...  / reaction / complex
 ENSMUSG00000059280 Vpreb2 / P13373 / pre-B lymphocyte gene 2 / VPREB1* / P12018* / V-set pre-B cell surrogate light chain 1*  / complex / reaction






 

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