ENSMUSG00000075370


Mus musculus

Features
Gene ID: ENSMUSG00000075370
  
Biological name :Igll1
  
Synonyms : Igll1 / Immunoglobulin lambda-like polypeptide 1 / P20764
  
Possible biological names infered from orthology : B9A064 / IGLC1 / IGLC2 / IGLC3 / IGLC7 / IGLL5 / immunoglobulin lambda constant 1 / immunoglobulin lambda constant 2 / immunoglobulin lambda constant 3 (Kern-Oz+ marker) / immunoglobulin lambda constant 7 / immunoglobulin lambda like polypeptide 5 / P0DOY2 / P0DOY3 / P15814
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 16860671
Gene end: 16863985
  
Corresponding Affymetrix probe sets: 10438060 (MoGene1.0st)   1420176_x_at (Mouse Genome 430 2.0 Array)   1420177_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097713
NCBI entrez gene - 16136     See in Manteia.
MGI - MGI:96529
RefSeq - NM_001190325
RefSeq Peptide - NP_001177254
swissprot - P20764
Ensembl - ENSMUSG00000075370
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU571382.4ENSDARG00000110539Danio rerio
 FP016018.1ENSDARG00000093689Danio rerio
 FP016018.4ENSDARG00000111019Danio rerio
 IGLL1ENSGALG00000021139Gallus gallus
 IGLC1ENSG00000211675Homo sapiens
 IGLC2ENSG00000211677Homo sapiens
 IGLC3ENSG00000211679Homo sapiens
 IGLC7ENSG00000211685Homo sapiens
 IGLL1ENSG00000128322Homo sapiens
 IGLL5ENSG00000254709Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Iglc1 / IGLC3* / IGLC7* / IGLL1* / IGLC2* / IGLL5* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 7* / immunoglobulin lambda constant 1* / immunoglobulin lambda co...ENSMUSG0000010590635
Iglc4 / IGLC2* / IGLC3* / IGLC7* / IGLL5* / IGLL1* / IGLC1* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 7* / immunoglobulin lambda constant 1* / immunoglobulin ...ENSMUSG0000010603931
Iglc3ENSMUSG0000010554730
Iglc2 / P01844 / Ig lambda-2 chain C region ENSMUSG0000007693729
Igkc / immunoglobulin kappa constantENSMUSG0000007660917


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0003823 antigen binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

Allelic Composition: Igll1tm1Cgn/Igll1tm1Cgn,Tg(Igk-V4CH27)1-2Shc/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Allelic Composition: Igktm1Rsky/Igk+,Igll1tm1Cgn/Igll1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0004976 abnormal B-1 B cell number "deviation from the normal count of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igktm1Rsky/Igk+,Igll1tm1Cgn/Igll1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0005020 abnormal late pro-B cell "anomalous structure, developoment, or number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igll1tm1Cgn/Igll1tm1Cgn,Tg(Igk-V4CH27)1-2Shc/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Allelic Composition: Igktm1Rsky/Igk+,Igll1tm1Cgn/Igll1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igktm1Rsky/Igk+,Igll1tm1Cgn/Igll1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igll1tm1Shim/Igll1tm1Shim,Vpreb1tm1Shim/Vpreb1tm1Shim,Vpreb2tm1Shim/Vpreb2tm1Shim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Igktm1Rsky/Igk+,Igll1tm1Cgn/Igll1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000903 Vpreb3 / pre-B lymphocyte gene 3 / Q9UKI3* / V-set pre-B cell surrogate light chain 3*  / complex / reaction
 ENSMUSG00000059305 P13372 / Vpreb1 / pre-B lymphocyte gene 1 / P12018* / V-set pre-B cell surrogate light chain 1*  / complex / reaction
 ENSMUSG00000059280 Vpreb2 / P13373 / pre-B lymphocyte gene 2 / VPREB1* / P12018* / V-set pre-B cell surrogate light chain 1*  / reaction / complex
 ENSMUSG00000075370 Igll1 / P20764 / Immunoglobulin lambda-like polypeptide 1 / IGLC3* / IGLC7* / IGLC2* / IGLL5* / IGLC1* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 1* / immunog...  / complex / reaction






 

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