ENSMUSG00000105906


Mus musculus

Features
Gene ID: ENSMUSG00000105906
  
Biological name :Iglc1
  
Synonyms : Iglc1
  
Possible biological names infered from orthology : B9A064 / IGLC2 / IGLC3 / IGLC7 / IGLL1 / IGLL5 / immunoglobulin lambda constant 1 / immunoglobulin lambda constant 2 / immunoglobulin lambda constant 3 (Kern-Oz+ marker) / immunoglobulin lambda constant 7 / immunoglobulin lambda like polypeptide 1 / immunoglobulin lambda like polypeptide 5 / P0DOY2 / P0DOY3 / P15814
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 19061618
Gene end: 19062071
  
Corresponding Affymetrix probe sets: 1424931_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142686
MGI - MGI:99546
swissprot - A0A0G2JE99
Ensembl - ENSMUSG00000105906
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU571382.4ENSDARG00000110539Danio rerio
 FP016018.1ENSDARG00000093689Danio rerio
 FP016018.4ENSDARG00000111019Danio rerio
 IGLL1ENSGALG00000021139Gallus gallus
 IGLC1ENSG00000211675Homo sapiens
 IGLC2ENSG00000211677Homo sapiens
 IGLC3ENSG00000211679Homo sapiens
 IGLC7ENSG00000211685Homo sapiens
 IGLL1ENSG00000128322Homo sapiens
 IGLL5ENSG00000254709Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Iglc4 / IGLC2* / IGLC3* / IGLC7* / IGLL5* / IGLL1* / IGLC1* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 7* / immunoglobulin lambda constant 1* / immunoglobulin ...ENSMUSG0000010603975
Igll1 / P20764 / Immunoglobulin lambda-like polypeptide 1 / IGLC3* / IGLC7* / IGLC2* / IGLL5* / IGLC1* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 1* / immunog...ENSMUSG0000007537070
Iglc3ENSMUSG0000010554763
Iglc2 / P01844 / Ig lambda-2 chain C region ENSMUSG0000007693762
Igkc / immunoglobulin kappa constantENSMUSG0000007660939


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0019815 B cell receptor complex IDA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0003823 antigen binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1.1Ust/Iglc1tm1.1Ust
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1.1Ust/Iglc1tm1.1Ust
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cplx2tm1Tyag/Cplx2tm1Tyag
Genetic Background: B6.Cg-Cplx2tm1Tyag

Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1.1Ust/Iglc1tm1.1Ust
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Igktm1Dhu/Igktm1Dhu,Iglc1tm1.1Ust/Iglc1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust,Ptpn6me-v/Ptpn6me-v
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008761 abnormal immunoglobulin light chain V-J recombination "any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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