ENSMUSG00000076609


Mus musculus

Features
Gene ID: ENSMUSG00000076609
  
Biological name :Igkc
  
Synonyms : Igkc / immunoglobulin kappa constant
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 70726435
Gene end: 70726966
  
Corresponding Affymetrix probe sets: 1427455_x_at (Mouse Genome 430 2.0 Array)   1427660_x_at (Mouse Genome 430 2.0 Array)   1452417_x_at (Mouse Genome 430 2.0 Array)   1452463_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100206
MGI - MGI:96495
swissprot - A0A075B5P2
Ensembl - ENSMUSG00000076609
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGKCENSG00000211592Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Iglc1 / IGLC3* / IGLC7* / IGLL1* / IGLC2* / IGLL5* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 7* / immunoglobulin lambda constant 1* / immunoglobulin lambda co...ENSMUSG0000010590638
Iglc4 / IGLC2* / IGLC3* / IGLC7* / IGLL5* / IGLL1* / IGLC1* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 7* / immunoglobulin lambda constant 1* / immunoglobulin ...ENSMUSG0000010603937
Iglc2 / P01844 / Ig lambda-2 chain C region ENSMUSG0000007693737
Iglc3ENSMUSG0000010554737
Igll1 / P20764 / Immunoglobulin lambda-like polypeptide 1 / IGLC3* / IGLC7* / IGLC2* / IGLL5* / IGLC1* / B9A064* / P0DOY2* / P0DOY3* / P15814* / immunoglobulin lambda constant 1* / immunog...ENSMUSG0000007537034


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
No match


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1.1Bgmn/Igltm1.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1Bgmn/Igltm1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1Bgmn/Igltm1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igkctm2(IGKC)Cgn/Igkctm2(IGKC)Cgn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: Not Specified

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/0,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ighmtm3Bgmn/Ighmtm3Bgmn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa13tm1Ipc/Hoxa13+,Hoxd13spdh/Hoxd13spdh
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2)J9.2Jkbv/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: Not Specified

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2)J9.2Jkbv/0,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2BM)7Amgn/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2CM)2Amgn/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yHG1/2)1Amgn/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yHG4)1Amgn/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: Not Specified

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0003134 increased number of late pro-B cells "greater number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, J:91592, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/0,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa13tm1Ipc/Hoxa13+,Hoxd13spdh/Hoxd13spdh
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2)J9.2Jkbv/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1.1Bgmn/Igltm1.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1Bgmn/Igltm1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1(IGKC)Mnz/Igkc+,Igk-Eiktm1(Igh)Xu/Igk-Eik+
Genetic Background: Not Specified

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2BM)7Amgn/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2CM)2Amgn/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1.1Bgmn/Igltm1.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1Bgmn/Igltm1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1.1Bgmn/Igltm1.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm2Bgmn/Igltm2Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0008202 absent B-1 B cells "absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1.1Bgmn/Igltm1.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1Bgmn/Igltm1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

 MP:0008205 absent B-2 cells "absence of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1.1Bgmn/Igltm1.1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1Bgmn/Igltm1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/0,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igkctm1Cgn/Igkc+
Genetic Background: involves: C57BL/6

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/0,Tg(IGK@yK1)9.2CJkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2)J9.2Jkbv/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: Not Specified

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/0,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2)J9.2Jkbv/0,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm1Bgmn/Igltm1Bgmn
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: Not Specified

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/0,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2)J9.2Jkbv/0,Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic Background: involves: 129P2/OlaHsd

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2)J9.2Jkbv/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129P2/OlaHsd

 MP:0008761 abnormal immunoglobulin light chain V-J recombination "any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Igh-Jtm1Jkbv/Igh-Jtm1Jkbv,Igkctm1Jkbv/Igkctm1Jkbv,Tg(IGH@yH2)J9.2Jkbv/0,Tg(IGK@yK2)J23.1Jkbv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Igkctm1Jkbv/Igkctm1Jkbv
Genetic Background: Not Specified

Allelic Composition: Igkctm1(IGKC)Mnz/Igkc+,Igk-Jtm1(CD4*)Mss/Igk-J+
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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