ENSMUSG00000059895


Mus musculus

Features
Gene ID: ENSMUSG00000059895
  
Biological name :Ptp4a3
  
Synonyms : Protein tyrosine phosphatase type IVA 3 / Ptp4a3 / Q9D658
  
Possible biological names infered from orthology : O75365 / protein tyrosine phosphatase type IVA, member 3
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 73723145
Gene end: 73758766
  
Corresponding Affymetrix probe sets: 10424607 (MoGene1.0st)   1418181_at (Mouse Genome 430 2.0 Array)   1418182_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155773
Ensembl peptide - ENSMUSP00000155312
Ensembl peptide - ENSMUSP00000155324
Ensembl peptide - ENSMUSP00000060956
Ensembl peptide - ENSMUSP00000131036
Ensembl peptide - ENSMUSP00000131281
Ensembl peptide - ENSMUSP00000132097
Ensembl peptide - ENSMUSP00000154829
NCBI entrez gene - 19245     See in Manteia.
MGI - MGI:1277098
RefSeq - XM_011245523
RefSeq - NM_001166388
RefSeq - NM_001166389
RefSeq - NM_001166390
RefSeq - NM_008975
RefSeq - XM_006520640
RefSeq - XM_006520642
RefSeq Peptide - NP_001159860
RefSeq Peptide - NP_001159861
RefSeq Peptide - NP_033001
RefSeq Peptide - NP_001159862
RefSeq Peptide - NP_001344520
swissprot - Q9D658
swissprot - E9PXS4
Ensembl - ENSMUSG00000059895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptp4a3ENSDARG00000039997Danio rerio
 si:ch211-251p5.5ENSDARG00000054814Danio rerio
 PTP4A3ENSGALG00000040969Gallus gallus
 O75365ENSG00000184489Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptp4a1 / Q63739 / protein tyrosine phosphatase 4a1 / Q93096* / protein tyrosine phosphatase type IVA, member 1*ENSMUSG0000002606475
O70274 / Ptp4a2 / Protein tyrosine phosphatase type IVA 2 / Q12974* / protein tyrosine phosphatase type IVA, member 2*ENSMUSG0000002878873


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043117 positive regulation of vascular permeability IMP
 biological_processGO:0043542 endothelial cell migration ISO
 biological_processGO:1900746 regulation of vascular endothelial growth factor signaling pathway IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISO
 biological_processGO:1904951 positive regulation of establishment of protein localization ISO
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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