ENSG00000184489


Homo sapiens

Features
Gene ID: ENSG00000184489
  
Biological name :PTP4A3
  
Synonyms : O75365 / protein tyrosine phosphatase type IVA, member 3 / PTP4A3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.3
Gene start: 141391993
Gene end: 141432454
  
Corresponding Affymetrix probe sets: 206574_s_at (Human Genome U133 Plus 2.0 Array)   209695_at (Human Genome U133 Plus 2.0 Array)   214223_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428758
Ensembl peptide - ENSP00000428725
Ensembl peptide - ENSP00000428976
Ensembl peptide - ENSP00000430332
Ensembl peptide - ENSP00000331730
Ensembl peptide - ENSP00000332274
NCBI entrez gene - 11156     See in Manteia.
OMIM - 606449
RefSeq - XM_017012999
RefSeq - XM_005250764
RefSeq - XM_006716500
RefSeq - XM_011516803
RefSeq - XM_011516805
RefSeq - XM_017012998
RefSeq - NM_007079
RefSeq - NM_032611
RefSeq Peptide - NP_009010
RefSeq Peptide - NP_116000
swissprot - E5RGR3
swissprot - O75365
swissprot - E5RFQ4
Ensembl - ENSG00000184489
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptp4a3ENSDARG00000039997Danio rerio
 si:ch211-251p5.5ENSDARG00000054814Danio rerio
 PTP4A3ENSGALG00000040969Gallus gallus
 Ptp4a3ENSMUSG00000059895Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTP4A1 / Q93096 / protein tyrosine phosphatase type IVA, member 1ENSG0000011224577
PTP4A2 / Q12974 / protein tyrosine phosphatase type IVA, member 2ENSG0000018400774


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:1900746 regulation of vascular endothelial growth factor signaling pathway IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 biological_processGO:1904951 positive regulation of establishment of protein localization IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004727 prenylated protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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