ENSMUSG00000028788


Mus musculus

Features
Gene ID: ENSMUSG00000028788
  
Biological name :Ptp4a2
  
Synonyms : O70274 / Protein tyrosine phosphatase type IVA 2 / Ptp4a2
  
Possible biological names infered from orthology : protein tyrosine phosphatase type IVA, member 2 / Q12974
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 129811219
Gene end: 129850003
  
Corresponding Affymetrix probe sets: 10508479 (MoGene1.0st)   1420612_s_at (Mouse Genome 430 2.0 Array)   1420613_at (Mouse Genome 430 2.0 Array)   1435129_at (Mouse Genome 430 2.0 Array)   1460707_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030578
Ensembl peptide - ENSMUSP00000125901
NCBI entrez gene - 19244     See in Manteia.
MGI - MGI:1277117
RefSeq - XM_017320045
RefSeq - NM_001164745
RefSeq - NM_008974
RefSeq - XM_006502863
RefSeq Peptide - NP_001158217
RefSeq Peptide - NP_033000
swissprot - O70274
Ensembl - ENSMUSG00000028788
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptp4a2aENSDARG00000087443Danio rerio
 ptp4a2bENSDARG00000035676Danio rerio
 PTP4A2ENSGALG00000003265Gallus gallus
 PTP4A2ENSG00000184007Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptp4a1 / Q63739 / protein tyrosine phosphatase 4a1 / Q93096* / protein tyrosine phosphatase type IVA, member 1*ENSMUSG0000002606488
Ptp4a3 / Q9D658 / Protein tyrosine phosphatase type IVA 3 / O75365* / protein tyrosine phosphatase type IVA, member 3*ENSMUSG0000005989576


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Avptm1Chron/Avptm1Chron
Genetic Background: involves: C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0012109 decreased trophoblast glycogen cell number "reduced number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [MGI:csmith]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038975 P53612 / Rabggtb / Rab geranylgeranyl transferase, b subunit / P53611* / Rab geranylgeranyltransferase beta subunit*  / reaction / complex






 

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