ENSMUSG00000060470


Mus musculus

Features
Gene ID: ENSMUSG00000060470
  
Biological name :Adgrg3
  
Synonyms : Adgrg3 / Adhesion G protein-coupled receptor G3 / Q8R0T6
  
Possible biological names infered from orthology : Q86Y34
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 95017692
Gene end: 95045250
  
Corresponding Affymetrix probe sets: 10574276 (MoGene1.0st)   1417894_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051079
Ensembl peptide - ENSMUSP00000148483
NCBI entrez gene - 54672     See in Manteia.
MGI - MGI:1859670
RefSeq - XM_006531200
RefSeq - NM_173036
RefSeq - XM_006531198
RefSeq - XM_006531199
RefSeq Peptide - NP_766624
swissprot - A0A1D5RLS0
swissprot - Q8R0T6
Ensembl - ENSMUSG00000060470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgrg3ENSDARG00000074782Danio rerio
 ADGRG3ENSGALG00000040627Gallus gallus
 ADGRG3ENSG00000182885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgrg1 / Q8K209 / Adhesion G-protein coupled receptor G1 ADGRG1 N-terminal fragment ADGRG1 C-terminal fragment / Q9Y653* / adhesion G protein-coupled receptor G1*ENSMUSG0000003178530
Adgrg2 / Q8CJ12 / Adhesion G-protein coupled receptor G2 / Q8IZP9*ENSMUSG0000003129828
Adgrg6 / Q6F3F9 / Adhesion G-protein coupled receptor G6 ADGRG6 N-terminal fragment ADGRG6 C-terminal fragment / Q86SQ4* / adhesion G protein-coupled receptor G6*ENSMUSG0000003911628
Adgrg5 / Q3V3Z3 / Adhesion G-protein coupled receptor G5 / Q8IZF4*ENSMUSG0000006157727
Adgrg7 / Q8BM96 / Adhesion G-protein coupled receptor G7 / Q96K78*ENSMUSG0000002275520
Adgrg4 / B7ZCC9 / Adhesion G-protein coupled receptor G4 / Q8IZF6*ENSMUSG000000538524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR003910  GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5
 IPR017981  GPCR, family 2-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0032792 negative regulation of CREB transcription factor activity IMP
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0009925 increased transitional stage T2 B cell number "greater number of a type of a transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0013802 abnormal IgG2 level "deviation from the normal levels of the total immunoglobulin class G2 level" [MGI:Annie_Speak]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0020174 abnormal IgG level "deviation from the normal levels of immunoglobulin class G level" [GOC:NV]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0020175 abnormal IgG1 level "deviation from the normal levels of immunoglobulin class G1 level" [GOC:NV]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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