ENSMUSG00000039116


Mus musculus

Features
Gene ID: ENSMUSG00000039116
  
Biological name :Adgrg6
  
Synonyms : Adgrg6 / Adhesion G-protein coupled receptor G6 ADGRG6 N-terminal fragment ADGRG6 C-terminal fragment / Q6F3F9
  
Possible biological names infered from orthology : adhesion G protein-coupled receptor G6 / Q86SQ4
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A2
Gene start: 14402583
Gene end: 14545179
  
Corresponding Affymetrix probe sets: 10367982 (MoGene1.0st)   1437408_at (Mouse Genome 430 2.0 Array)   1437409_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043055
Ensembl peptide - ENSMUSP00000146821
NCBI entrez gene - 215798     See in Manteia.
MGI - MGI:1916151
RefSeq - XM_017313881
RefSeq - NM_001002268
RefSeq - XM_006512680
RefSeq - XM_006512681
RefSeq - XM_006512682
RefSeq - XM_006512678
RefSeq - XM_006512679
RefSeq Peptide - NP_001002268
swissprot - Q6F3F9
swissprot - A0A140LIH4
Ensembl - ENSMUSG00000039116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgrg6ENSDARG00000054137Danio rerio
 ADGRG6ENSGALG00000013803Gallus gallus
 ADGRG6ENSG00000112414Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgrg2 / Q8CJ12 / Adhesion G-protein coupled receptor G2 / Q8IZP9*ENSMUSG0000003129827
Adgrg1 / Q8K209 / Adhesion G-protein coupled receptor G1 ADGRG1 N-terminal fragment ADGRG1 C-terminal fragment / Q9Y653* / adhesion G protein-coupled receptor G1*ENSMUSG0000003178515
Adgrg7 / Q8BM96 / Adhesion G-protein coupled receptor G7 / Q96K78*ENSMUSG0000002275514
Adgrg3 / Q8R0T6 / Adhesion G protein-coupled receptor G3 / Q86Y34*ENSMUSG0000006047013
Adgrg5 / Q3V3Z3 / Adhesion G-protein coupled receptor G5 / Q8IZF4*ENSMUSG0000006157712
Adgrg4 / B7ZCC9 / Adhesion G-protein coupled receptor G4 / Q8IZF6*ENSMUSG000000538525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR000859  CUB domain
 IPR001759  Pentraxin-related
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0014037 Schwann cell differentiation IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0042552 myelination IEA
 biological_processGO:0060347 heart trabecula formation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding ISS
 molecular_functionGO:0043236 laminin binding IMP
 molecular_functionGO:0050840 extracellular matrix binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008069 abnormal joint mobility "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0010503 myocardial trabeculae hypoplasia "underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrg6tm1Taki/Adgrg6tm1Taki
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Adgrg6tm1Taki/Adgrg6tm1Taki
Genetic Background: involves: C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0011633 abnormal mitochondrial shape "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith]
Show

Allelic Composition: Adgrg6tm1Taki/Adgrg6tm1Taki
Genetic Background: involves: C57BL/6

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
Show

Allelic Composition: Adgrg6tm1Taki/Adgrg6tm1Taki
Genetic Background: involves: C57BL/6

 MP:0020452 abnormal axon radial sorting "any anomaly in the process by which immature Schwann cells surround axons of mixed caliber and send cytoplasmic processes that resemble lamellipodia between axons, to progressively choose and segregate the larger axons at the periphery of the bundle" [MGI:smb, PMID:25686621]
Show

Allelic Composition: Tbx21tm2Srnr/Tbx21+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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