ENSMUSG00000061315


Mus musculus

Features
Gene ID: ENSMUSG00000061315
  
Biological name :Naca
  
Synonyms : Naca / Nascent polypeptide-associated complex subunit alpha, muscle-specific form / P70670 / Q60817
  
Possible biological names infered from orthology : NACA2 / nascent polypeptide associated complex alpha subunit 2 / Q9H009
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128035575
Gene end: 128048637
  
Corresponding Affymetrix probe sets: 10367091 (MoGene1.0st)   10401958 (MoGene1.0st)   1416669_s_at (Mouse Genome 430 2.0 Array)   1448430_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073532
Ensembl peptide - ENSMUSP00000089680
NCBI entrez gene - 17938     See in Manteia.
MGI - MGI:106095
RefSeq - NM_013608
RefSeq - NM_001113199
RefSeq - NM_001282976
RefSeq Peptide - NP_001106670
RefSeq Peptide - NP_001269905
RefSeq Peptide - NP_038636
swissprot - P70670
swissprot - Q60817
Ensembl - ENSMUSG00000061315
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nacaENSDARG00000005513Danio rerio
 NACA2ENSG00000253506Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nacad / Q5SWP3 / NAC-alpha domain-containing protein 1 / O15069* / NAC alpha domain containing*ENSMUSG0000004107312


Protein motifs (from Interpro)
Interpro ID Name
 IPR002715  Nascent polypeptide-associated complex NAC domain
 IPR016641  Nascent polypeptide-associated complex subunit alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003231 cardiac ventricle development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010664 negative regulation of striated muscle cell apoptotic process IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043403 skeletal muscle tissue regeneration IMP
 biological_processGO:0048633 positive regulation of skeletal muscle tissue growth IMP
 biological_processGO:0048742 regulation of skeletal muscle fiber development IMP
 biological_processGO:0051451 myoblast migration IMP
 biological_processGO:0061384 heart trabecula morphogenesis IMP
 biological_processGO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development IMP
 biological_processGO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development IMP
 biological_processGO:2000138 positive regulation of cell proliferation involved in heart morphogenesis IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005854 nascent polypeptide-associated complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0017025 TBP-class protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Peg3tm1a(EUCOMM)Hmgu/Peg3+
Genetic Background: involves: C57BL/6N

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Peg3tm1a(EUCOMM)Hmgu/Peg3+
Genetic Background: involves: C57BL/6N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008753 abnormal osteocyte morphology "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010924 abnormal osteoid morphology "any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010927 decreased osteoid volume "reduction in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010930 decreased osteoid thickness "reduction in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Nacatm1Dsr/Nacatm1Dsr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

 MP:0030482 increased osteocyte number "greater than average number of mature osteoblasts that have become embedded in the bone matrix (osteoid) in small cavities called lacunae and that extend cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [MGI:anna]
Show

Allelic Composition: Atf2tm1Sis/Atf2+,Creb5tm1Sis/Creb5+
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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