Manteia - Molecule gene

ENSMUSG00000062078

Mus musculus

Features

Gene ID:	ENSMUSG00000062078

Biological name :	Qk

Synonyms :	Protein quaking / Q9QYS9 / Qk

Possible biological names infered from orthology :	Q96PU8 / QKI / QKI, KH domain containing RNA binding

Species:	Mus musculus

Chr. number:	17
Strand:	-1
Band:	A1
Gene start:	10206471
Gene end:	10319361

Corresponding Affymetrix probe sets:	10447708 (MoGene1.0st) 1417073_a_at (Mouse Genome 430 2.0 Array) 1425597_a_at (Mouse Genome 430 2.0 Array) 1429318_a_at (Mouse Genome 430 2.0 Array) 1429735_at (Mouse Genome 430 2.0 Array) 1429736_at (Mouse Genome 430 2.0 Array) 1441964_at (Mouse Genome 430 2.0 Array) 1451179_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000046740 Ensembl peptide - ENSMUSP00000095025 NCBI entrez gene - 19317 See in Manteia. MGI - MGI:97837 RefSeq - XM_006523300 RefSeq - NM_001159516 RefSeq - NM_001159517 RefSeq - NM_021881 RefSeq Peptide - NP_001152989 RefSeq Peptide - NP_068681 RefSeq Peptide - NP_001152988 swissprot - Q9QYS9 Ensembl - ENSMUSG00000062078

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
qkia	ENSDARG00000097478	Danio rerio
QKI	ENSGALG00000011555	Gallus gallus
QKI	ENSG00000112531	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q60749 / Khdrbs1 / KH domain-containing, RNA-binding, signal transduction-associated protein 1 / Q07666* / KH RNA binding domain containing, signal transduction associated 1*	ENSMUSG00000028790	33
Q9WU01 / Khdrbs2 / KH domain-containing, RNA-binding, signal transduction-associated protein 2 / Q5VWX1* / KH RNA binding domain containing, signal transduction associated 2*	ENSMUSG00000026058	31
Q9R226 / Khdrbs3 / KH domain-containing, RNA-binding, signal transduction-associated protein 3 / O75525* / KH RNA binding domain containing, signal transduction associated 3*	ENSMUSG00000022332	31
Sf1 / Q64213 / Splicing factor 1 / Q15637*	ENSMUSG00000024949	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR004087	K Homology domain
IPR004088	K Homology domain, type 1
IPR032367	Protein quaking, putative nuclear localisation signal
IPR032377	STAR protein, homodimerisation region
IPR036612	K Homology domain, type 1 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001570	vasculogenesis	IMP
biological_process	GO:0006397	mRNA processing	IEA
biological_process	GO:0006417	regulation of translation	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007286	spermatid development	IGI
biological_process	GO:0008366	axon ensheathment	IMP
biological_process	GO:0008380	RNA splicing	IEA
biological_process	GO:0010628	positive regulation of gene expression	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0042552	myelination	IMP
biological_process	GO:0042692	muscle cell differentiation	IMP
biological_process	GO:0042759	long-chain fatty acid biosynthetic process	IMP
biological_process	GO:0051028	mRNA transport	IEA
biological_process	GO:0061158	3"-UTR-mediated mRNA destabilization	IDA
cellular_component	GO:0005634	nucleus	IMP
cellular_component	GO:0005737	cytoplasm	IDA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003723	RNA binding	TAS
molecular_function	GO:0003729	mRNA binding	IDA
molecular_function	GO:0017124	SH3 domain binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000260	abnormal angiogenesis	"aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR Allelic Composition: Qk^qk-kt1/Qk^qk-kt1 Genetic Background: involves: STOCK t^w5
MP:0000269	abnormal looping morphogenesis	"atypical bending of the primitive heart tube during early development" [J:27443]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Del(17)T^Orl/+,Qk^qk-v/Qk⁺ Genetic Background: involves: C57BL/6J * Orl:Swiss
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sox10^df8R/Sox10⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Qk^e5/Qk^qk-kt1 Genetic Background: involves: 101/Rl * C57BL/6J Allelic Composition: Qk^e5/Qk^qk-k2 Genetic Background: involves: 101/Rl * C57BL/6J * CBA/Ca Allelic Composition: Qk^qk-2J/Qk^qk-2J Genetic Background: B6.Cg-Qk^qk-2J/GrsrJ Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: involves: C3H/Di * DBA/2J Allelic Composition: Del(17)T^Orl/+,Qk^qk-v/Qk⁺ Genetic Background: involves: C57BL/6J * Orl:Swiss Allelic Composition: Qk^qk-shk/Qk^qk-shk Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Qk^qk-2J/Qk^qk-shk Genetic Background: involves: 129 * C57BL/6 * C57BLKS/J
MP:0000876	Purkinje cell degeneration	"a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]	Show Allelic Composition: Sox10^df8R/Sox10⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox10^df8R/Sox10⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: involves: C3H/Di * DBA/2J
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Qk^qk-shk/Qk^qk-shk Genetic Background: involves: 129 * C57BL/6
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0000930	wavy neural tube	"undulations in the embryonic neural tube" [J:37888]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0000953	abnormal oligodendrocyte morphology	"anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sox10^df8R/Sox10⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J
MP:0001388	abnormal stationary movement	"altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ar^Tfm/Y Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo
MP:0001392	abnormal locomotor activity	"altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ar^Tfm/Y Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Sox10^df8R/Sox10⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Ar^Tfm/Y Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Qk^qk-shk/Qk^qk-shk Genetic Background: involves: 129 * C57BL/6
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Ar^Tfm/Y Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo
MP:0001407	short stride length	"reduced average distance between steps" [J:34193]	Show Allelic Composition: Qk^qk-shk/Qk^qk-shk Genetic Background: involves: 129 * C57BL/6
MP:0001441	increased grooming behavior	"increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ar^Tfm/Y Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0001622	abnormal vasculogenesis	"aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca
MP:0001701	incomplete embryo turning	"arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0001718	abnormal yolk sac	"malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Qk^qk-k2/Qk^qk-kt4 Genetic Background: involves: C57BL/6 * CBA/Ca * STOCK t^w5
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: involves: C3H/Di * DBA/2J
MP:0001932	abnormal spermiogenesis	"failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox10^df8R/Sox10⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Qk^e5/Qk^qk-kt1 Genetic Background: involves: 101/Rl * C57BL/6J Allelic Composition: Qk^e5/Qk^qk-k2 Genetic Background: involves: 101/Rl * C57BL/6J * CBA/Ca Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor Genetic Background: involves: 129P2/OlaHsd
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox10^df8R/Sox10⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il2^tm1Hor/Il2^tm1Hor Genetic Background: involves: 129P2/OlaHsd
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0002396	abnormal hematopoietic system morphology/development	"any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J Allelic Composition: Qk^qk-v/Qk^qk-v,Tg(PGK2-Pacrg)#Jus/? Genetic Background: involves: BTBR * C57BL/6J * DBA/2
MP:0002826	tonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: involves: C3H/Di * DBA/2J Allelic Composition: Qk^qk-shk/Qk^qk-shk Genetic Background: involves: 129 * C57BL/6
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR
MP:0003461	abnormal response to novel object	"altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Ar^Tfm/Y Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo
MP:0003492	abnormal involuntary movement	"anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]	Show Allelic Composition: Del(17)T^Orl/+,Qk^qk-v/Qk⁺ Genetic Background: involves: C57BL/6J * Orl:Swiss
MP:0003861	abnormal nervous system development	"impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca
MP:0003871	abnormal myelin sheath morphology	"malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Qk^qk-2J/Qk^qk-2J Genetic Background: B6.Cg-Qk^qk-2J/GrsrJ
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR
MP:0004077	abnormal striatum morphology	"malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Qk^qk-2J/Qk^qk-2J Genetic Background: B6.Cg-Qk^qk-2J/GrsrJ
MP:0004814	reduced linear vestibular evoked potential	"reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J
MP:0005221	abnormal rostral-caudal axis patterning	"anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Qk^qk-kt1/Qk^qk-kt1 Genetic Background: involves: STOCK t^w5
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas
MP:0005657	abnormal neural plate morphology	"malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca
MP:0006057	decreased vascular endothelial cell number	"less than normal number of cells lining the vasculature" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca
MP:0006281	abnormal tail development	"anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR
MP:0006386	absent somites	"missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca
MP:0008026	abnormal brain white matter morphology	"any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox10^df8R/Sox10⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0008530	abnormal rostral-caudal patterning of the somites	"anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Qk^qk-kt1/Qk^qk-kt1 Genetic Background: involves: STOCK t^w5
MP:0008533	abnormal anterior visceral endoderm	"any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR
MP:0008892	abnormal sperm flagellum	"any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J
MP:0009230	abnormal sperm head morphology	"any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J
MP:0009325	necrospermia	"condition in which spermatozoa in seminal fluid are dead or motionless" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J
MP:0009434	paraparesis	"a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: involves: C3H/Di * DBA/2J
MP:0010734	abnormal paranode morphology	"any structural anomaly of the axon region immediately adjacent to nodes of Ranvier, where a series of cytoplasmic loops from the overlying glial cell form septate-like junctions with the axon; the axoglial junctions act as a diffusion barrier between the node and internode" [PMID:16224497]	Show Allelic Composition: Qk^qk-shk/Qk^qk-shk Genetic Background: involves: 129 * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Qk^qk-2J/Qk^qk-2J Genetic Background: B6.Cg-Qk^qk-2J/GrsrJ
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Qk^qk-k2/Qk^qk-kt4 Genetic Background: involves: C57BL/6 * CBA/Ca * STOCK t^w5
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Qk^qk-kt1/Qk^qk-kt1 Genetic Background: involves: STOCK t^w5
MP:0011095	complete embryonic lethality between implantation and placentation	"death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca
MP:0011097	complete embryonic lethality before turning of embryo	"death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Rara^tm2Ipc/Rara^tm2Ipc,Rarb^tm1Ipc/Rarb^tm1Ipc Genetic Background: involves: 129S2/SvPas Allelic Composition: Qk^qk-k2/Qk^qk-k2 Genetic Background: involves: C57BL/6 * CBA/Ca Allelic Composition: Qk^qk-l1/Qk^qk-l1 Genetic Background: involves: BTBR
MP:0011257	abnormal head fold morphology	"any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]	Show Allelic Composition: Qk^qk-kt1/Qk^qk-kt1 Genetic Background: involves: STOCK t^w5
MP:0011731	decreased myelin sheath thickness	"decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]	Show Allelic Composition: Qk^qk-shk/Qk^qk-shk Genetic Background: involves: 129 * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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