ENSMUSG00000026058


Mus musculus

Features
Gene ID: ENSMUSG00000026058
  
Biological name :Khdrbs2
  
Synonyms : KH domain-containing, RNA-binding, signal transduction-associated protein 2 / Khdrbs2 / Q9WU01
  
Possible biological names infered from orthology : KH RNA binding domain containing, signal transduction associated 2 / Q5VWX1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 32172714
Gene end: 32658568
  
Corresponding Affymetrix probe sets: 10345212 (MoGene1.0st)   1422117_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140157
Ensembl peptide - ENSMUSP00000141095
Ensembl peptide - ENSMUSP00000140451
Ensembl peptide - ENSMUSP00000027226
NCBI entrez gene - 170771     See in Manteia.
MGI - MGI:2159649
RefSeq - NM_133235
RefSeq Peptide - NP_573498
swissprot - A0A087WSL3
swissprot - A0A087WR32
swissprot - Q9WU01
Ensembl - ENSMUSG00000026058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q08BJ2ENSDARG00000069469Danio rerio
 KHDRBS2ENSGALG00000016276Gallus gallus
 Q5VWX1ENSG00000112232Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R226 / Khdrbs3 / KH domain-containing, RNA-binding, signal transduction-associated protein 3 / O75525* / KH RNA binding domain containing, signal transduction associated 3*ENSMUSG0000002233265
Q60749 / Khdrbs1 / KH domain-containing, RNA-binding, signal transduction-associated protein 1 / Q07666* / KH RNA binding domain containing, signal transduction associated 1*ENSMUSG0000002879062
Qk / Q9QYS9 / Protein quaking / QKI* / Q96PU8* / QKI, KH domain containing RNA binding*ENSMUSG0000006207830
Sf1 / Q64213 / Splicing factor 1 / Q15637*ENSMUSG0000002494927


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR032335  Sam68, tyrosine-rich domain
 IPR032571  KHDRBS, Qua1 domain
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0048024 regulation of mRNA splicing, via spliceosome IDA
 cellular_componentGO:0005634 nucleus TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008143 poly(A) binding IDA
 molecular_functionGO:0008266 poly(U) RNA binding IDA
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0042169 SH2 domain binding IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
PTK6 Regulates Proteins Involved in RNA Processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Setd1btm1.3Afst/Setd1btm1.3Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Setd1btm1.3Afst/Setd1btm1.3Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd,Khdrbs2tm1.1Schei/Khdrbs2tm1.1Schei
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ

 MP:0000884 delaminated Purkinje cell layer "splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd,Khdrbs2tm1.1Schei/Khdrbs2tm1.1Schei
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Setd1btm1.3Afst/Setd1btm1.3Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0003267 constipation "incomplete, infrequent or difficult evacuation of fecal matter " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

 MP:0004250 tau protein deposits "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Khdrbs2Tg(LRRK2*R1441G)135Cjli/Khdrbs2+
Genetic Background: FVB/N-Khdrbs2Tg(LRRK2*R1441G)135Cjli/J

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd,Khdrbs2tm1.1Schei/Khdrbs2tm1.1Schei
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction






 

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