ENSMUSG00000024949


Mus musculus

Features
Gene ID: ENSMUSG00000024949
  
Biological name :Sf1
  
Synonyms : Q64213 / Sf1 / Splicing factor 1
  
Possible biological names infered from orthology : Q15637
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 6363690
Gene end: 6378030
  
Corresponding Affymetrix probe sets: 10460926 (MoGene1.0st)   1422321_a_at (Mouse Genome 430 2.0 Array)   1423750_a_at (Mouse Genome 430 2.0 Array)   1423751_at (Mouse Genome 430 2.0 Array)   1459765_s_at (Mouse Genome 430 2.0 Array)   1459766_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114788
Ensembl peptide - ENSMUSP00000114438
Ensembl peptide - ENSMUSP00000117172
Ensembl peptide - ENSMUSP00000124590
Ensembl peptide - ENSMUSP00000123175
Ensembl peptide - ENSMUSP00000121309
Ensembl peptide - ENSMUSP00000109113
Ensembl peptide - ENSMUSP00000109115
Ensembl peptide - ENSMUSP00000109116
Ensembl peptide - ENSMUSP00000109117
NCBI entrez gene - 22668     See in Manteia.
MGI - MGI:1095403
RefSeq - XM_017318187
RefSeq - NM_001110791
RefSeq - NM_011750
RefSeq - XM_006531733
RefSeq - XM_006531734
RefSeq - XM_006531735
RefSeq - XM_006531736
RefSeq - XM_006531737
RefSeq - XM_006531738
RefSeq - XM_006531740
RefSeq Peptide - NP_001104261
RefSeq Peptide - NP_035880
swissprot - E9Q4Q2
swissprot - D6RDB7
swissprot - D3YZD0
swissprot - F6SRV1
swissprot - F6YR19
swissprot - F6Z9W2
swissprot - F8WHF9
swissprot - D3YZC9
swissprot - D3YVH4
swissprot - Q64213
swissprot - Q3UI45
Ensembl - ENSMUSG00000024949
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sf1ENSDARG00000008188Danio rerio
 SF1ENSG00000168066Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Qk / Q9QYS9 / Protein quaking / QKI* / Q96PU8* / QKI, KH domain containing RNA binding*ENSMUSG0000006207816
Q9R226 / Khdrbs3 / KH domain-containing, RNA-binding, signal transduction-associated protein 3 / O75525* / KH RNA binding domain containing, signal transduction associated 3*ENSMUSG0000002233215
Q9WU01 / Khdrbs2 / KH domain-containing, RNA-binding, signal transduction-associated protein 2 / Q5VWX1* / KH RNA binding domain containing, signal transduction associated 2*ENSMUSG0000002605815
Q60749 / Khdrbs1 / KH domain-containing, RNA-binding, signal transduction-associated protein 1 / Q07666* / KH RNA binding domain containing, signal transduction associated 1*ENSMUSG0000002879014


Protein motifs (from Interpro)
Interpro ID Name
 IPR001878  Zinc finger, CCHC-type
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR031150  BBP/SF1 family
 IPR032570  Splicing factor 1, helix-hairpin domain
 IPR036612  K Homology domain, type 1 superfamily
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0030238 male sex determination IGI
 biological_processGO:0030575 nuclear body organization IMP
 biological_processGO:0033327 Leydig cell differentiation IGI
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050810 regulation of steroid biosynthetic process IGI
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045131 pre-mRNA branch point binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Dnd1Ter/Dnd1Ter,Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dnd1Ter/Dnd1Ter,Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trpv3tm1.2Clph/Trpv3tm1.2Clph
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-112K/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-112K/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
Show

Allelic Composition: Dnd1Ter/Dnd1Ter,Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv

Allelic Composition: Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * MOLF/Ei

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Tyrc-112K/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Trpv3tm1.2Clph/Trpv3tm1.2Clph
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr