ENSG00000168066


Homo sapiens

Features
Gene ID: ENSG00000168066
  
Biological name :SF1
  
Synonyms : Q15637 / SF1 / splicing factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.1
Gene start: 64764606
Gene end: 64778786
  
Corresponding Affymetrix probe sets: 1555749_at (Human Genome U133 Plus 2.0 Array)   208313_s_at (Human Genome U133 Plus 2.0 Array)   210172_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395927
Ensembl peptide - ENSP00000391198
Ensembl peptide - ENSP00000396793
Ensembl peptide - ENSP00000486693
Ensembl peptide - ENSP00000419062
Ensembl peptide - ENSP00000407962
Ensembl peptide - ENSP00000406354
Ensembl peptide - ENSP00000227503
Ensembl peptide - ENSP00000334414
Ensembl peptide - ENSP00000366604
Ensembl peptide - ENSP00000366607
Ensembl peptide - ENSP00000366611
Ensembl peptide - ENSP00000388470
NCBI entrez gene - 7536     See in Manteia.
OMIM - 601516
RefSeq - XM_017018251
RefSeq - NM_001178031
RefSeq - NM_001346363
RefSeq - NM_001346364
RefSeq - NM_001346409
RefSeq - NM_001346410
RefSeq - NM_004630
RefSeq - NM_201995
RefSeq - NM_201997
RefSeq - NM_201998
RefSeq - XM_011545244
RefSeq - XM_011545245
RefSeq - XM_011545246
RefSeq - XM_011545247
RefSeq - XM_011545248
RefSeq - XM_017018244
RefSeq - XM_017018245
RefSeq - XM_017018246
RefSeq - XM_017018247
RefSeq - XM_017018248
RefSeq - XM_017018249
RefSeq - XM_017018250
RefSeq - NM_001178030
RefSeq Peptide - NP_001171502
RefSeq Peptide - NP_001333292
RefSeq Peptide - NP_001333293
RefSeq Peptide - NP_001333338
RefSeq Peptide - NP_001333339
RefSeq Peptide - NP_004621
RefSeq Peptide - NP_973724
RefSeq Peptide - NP_973726
RefSeq Peptide - NP_973727
RefSeq Peptide - NP_001171501
swissprot - C9J792
swissprot - Q15637
swissprot - A0A024R5D9
swissprot - A0A024R588
swissprot - A0A024R572
swissprot - F8WEG7
swissprot - F8WEV5
swissprot - H7BZT1
swissprot - H7C0N4
swissprot - H7C561
swissprot - A0A024R566
Ensembl - ENSG00000168066
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sf1ENSDARG00000008188Danio rerio
 Sf1ENSMUSG00000024949Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q07666 / KHDRBS1 / KH RNA binding domain containing, signal transduction associated 1ENSG0000012177415
QKI / Q96PU8 / QKI, KH domain containing RNA bindingENSG0000011253114
O75525 / KHDRBS3 / KH RNA binding domain containing, signal transduction associated 3ENSG0000013177313
Q5VWX1 / KHDRBS2 / KH RNA binding domain containing, signal transduction associated 2ENSG0000011223213


Protein motifs (from Interpro)
Interpro ID Name
 IPR001878  Zinc finger, CCHC-type
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR031150  BBP/SF1 family
 IPR032570  Splicing factor 1, helix-hairpin domain
 IPR036612  K Homology domain, type 1 superfamily
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000245 spliceosomal complex assembly NAS
 biological_processGO:0000389 mRNA 3"-splice site recognition TAS
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0030238 male sex determination IEA
 biological_processGO:0030575 nuclear body organization IEA
 biological_processGO:0033327 Leydig cell differentiation IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050810 regulation of steroid biosynthetic process IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005681 spliceosomal complex IDA
 cellular_componentGO:0005840 ribosome NAS
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045131 pre-mRNA branch point binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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