ENSG00000121774


Homo sapiens

Features
Gene ID: ENSG00000121774
  
Biological name :KHDRBS1
  
Synonyms : KHDRBS1 / KH RNA binding domain containing, signal transduction associated 1 / Q07666
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p35.2
Gene start: 32013829
Gene end: 32060850
  
Corresponding Affymetrix probe sets: 200040_at (Human Genome U133 Plus 2.0 Array)   201488_x_at (Human Genome U133 Plus 2.0 Array)   214185_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000313829
Ensembl peptide - ENSP00000417731
NCBI entrez gene - 10657     See in Manteia.
OMIM - 602489
RefSeq - NM_001271878
RefSeq - NM_006559
RefSeq Peptide - NP_001258807
RefSeq Peptide - NP_006550
swissprot - Q07666
Ensembl - ENSG00000121774
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 khdrbs1aENSDARG00000052856Danio rerio
 khdrbs1bENSDARG00000070475Danio rerio
 KHDRBS1ENSGALG00000003272Gallus gallus
 Q60749ENSMUSG00000028790Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5VWX1 / KHDRBS2 / KH RNA binding domain containing, signal transduction associated 2ENSG0000011223250
O75525 / KHDRBS3 / KH RNA binding domain containing, signal transduction associated 3ENSG0000013177345
QKI / Q96PU8 / QKI, KH domain containing RNA bindingENSG0000011253125
SF1 / Q15637 / splicing factor 1ENSG0000016806622


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR032335  Sam68, tyrosine-rich domain
 IPR032571  KHDRBS, Qua1 domain
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045948 positive regulation of translational initiation IDA
 biological_processGO:0046831 regulation of RNA export from nucleus ISS
 biological_processGO:0046833 positive regulation of RNA export from nucleus IDA
 biological_processGO:0048024 regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070618 Grb2-Sos complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008143 poly(A) binding IDA
 molecular_functionGO:0008266 poly(U) RNA binding IDA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding IDA


Pathways (from Reactome)
Pathway description
PTK6 Regulates Proteins Involved in RNA Processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction / complex






 

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