ENSMUSG00000063133


Mus musculus

Features
Gene ID: ENSMUSG00000063133
  
Biological name :Klk1b1
  
Synonyms : Kallikrein 1-related peptidase b1 / Klk1b1 / P00755
  
Possible biological names infered from orthology : kallikrein 1 / kallikrein related peptidase 2 / kallikrein related peptidase 3 / KLK1 / KLK2 / KLK3 / P06870 / P07288 / P20151
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 43966751
Gene end: 43971318
  
Corresponding Affymetrix probe sets: 10552562 (MoGene1.0st)   1420701_at (Mouse Genome 430 2.0 Array)   1425182_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077879
NCBI entrez gene - 16623     See in Manteia.
MGI - MGI:892019
RefSeq - NM_010645
RefSeq Peptide - NP_034775
swissprot - A0A1R3UCH6
swissprot - P00755
Ensembl - ENSMUSG00000063133
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLK1ENSG00000167748Homo sapiens
 KLK2ENSG00000167751Homo sapiens
 KLK3ENSG00000142515Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klk1b9 / P15949 / Kallikrein 1-related peptidase b9 / KLK1* / KLK3* / KLK2* / P06870* / P07288* / P20151* / kallikrein 1* / kallikrein related peptidase 3* / kallikrein related peptidase 2*ENSMUSG0000005904287
Klk1b3 / P00756 / Kallikrein 1-related peptidase b3 Nerve growth factor gamma chain 1 Nerve growth factor gamma chain 2 / KLK1* / KLK3* / KLK2* / P20151* / P06870* / P07288* / kallikrein 1*...ENSMUSG0000006651581
Q9JM71 / Klk1b27 / Kallikrein 1-related peptidase b27 / KLK2* / KLK1* / KLK3* / P06870* / P07288* / P20151* / kallikrein 1* / kallikrein related peptidase 2* / kallikrein related peptidase 3*ENSMUSG0000006317779
P15946 / Klk1b11 / Kallikrein 1-related peptidase b11 / KLK2* / KLK3* / KLK1* / P20151* / P06870* / P07288* / kallikrein 1* / kallikrein related peptidase 2* / kallikrein related peptidase 3*ENSMUSG0000004448579
Q61754 / Klk1b24 / Kallikrein 1-related peptidase b24 / KLK2* / KLK1* / KLK3* / P06870* / P07288* / P20151* / kallikrein 1* / kallikrein related peptidase 2* / kallikrein related peptidase 3*ENSMUSG0000006371378
Q61759 / Klk1b21 / Kallikrein 1-related peptidase b21 / KLK2* / KLK1* / KLK3* / P06870* / P07288* / P20151* / kallikrein 1* / kallikrein related peptidase 2* / kallikrein related peptidase 3*ENSMUSG0000006651678
Klk1b5 / P15945 / Kallikrein 1-related peptidase b5 / KLK1* / KLK3* / KLK2* / P06870* / P07288* / P20151* / kallikrein 1* / kallikrein related peptidase 3* / kallikrein related peptidase 2*ENSMUSG0000006651277
P15948 / Klk1b22 / kallikrein 1-related peptidase b22 / KLK2* / KLK3* / KLK1* / P20151* / P06870* / P07288* / kallikrein 1* / kallikrein related peptidase 2* / kallikrein related peptidase 3*ENSMUSG0000006017777
Klk1 / P15947 / Kallikrein-1 / KLK2* / KLK3* / P20151* / P06870* / P07288* / kallikrein related peptidase 2* / kallikrein related peptidase 3*ENSMUSG0000006390375
Klk1b4 / P00757 / Kallikrein 1-related peptidase-like b4 / KLK1* / KLK3* / KLK2* / P20151* / P06870* / P07288* / kallikrein 1* / kallikrein related peptidase 3* / kallikrein related peptidase 2*ENSMUSG0000006651375
P36369 / Klk1b26 / Kallikrein 1-related peptidase b26 / KLK2* / KLK1* / KLK3* / P06870* / P07288* / P20151* / kallikrein 1* / kallikrein related peptidase 2* / kallikrein related peptidase 3*ENSMUSG0000005371975
P04071 / Klk1b16 / Kallikrein 1-related peptidase b16 / KLK2* / KLK3* / KLK1* / P20151* / P06870* / P07288* / kallikrein 1* / kallikrein related peptidase 2* / kallikrein related peptidase 3*ENSMUSG0000003896872
Klk1b8 / P07628 / Kallikrein 1-related peptidase b8 / KLK1* / KLK3* / KLK2* / P06870* / P07288* / P20151* / kallikrein 1* / kallikrein related peptidase 3* / kallikrein related peptidase 2*ENSMUSG0000006308972


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002255 tissue kallikrein-kinin cascade IMP
 biological_processGO:0002936 bradykinin biosynthetic process IMP
 biological_processGO:0003073 regulation of systemic arterial blood pressure IMP
 biological_processGO:0003220 left ventricular cardiac muscle tissue morphogenesis IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0042311 vasodilation IMP
 biological_processGO:0060048 cardiac muscle contraction IMP
 cellular_componentGO:0005615 extracellular space ISO
 molecular_functionGO:0004175 endopeptidase activity ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ISO


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pax9tm1Hpt/Pax9tm1Rbal
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003995 abnormal uterine artery morphology "malformation of the branch of the internal iliac artery that supplies the uterus and the upper part of the vagina" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Klk1b1tm1Pmtn/Klk1b1tm1Pmtn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Klk1b1tm1Pmtn/Klk1b1tm1Pmtn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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