ENSMUSG00000063550


Mus musculus

Features
Gene ID: ENSMUSG00000063550
  
Biological name :Nup98
  
Synonyms : nucleoporin 98 / Nup98
  
Possible biological names infered from orthology : P52948
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 102119398
Gene end: 102210176
  
Corresponding Affymetrix probe sets: 10566097 (MoGene1.0st)   1434220_at (Mouse Genome 430 2.0 Array)   1439154_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147807
Ensembl peptide - ENSMUSP00000147445
Ensembl peptide - ENSMUSP00000148115
Ensembl peptide - ENSMUSP00000068530
Ensembl peptide - ENSMUSP00000147486
Ensembl peptide - ENSMUSP00000147454
NCBI entrez gene - 269966     See in Manteia.
MGI - MGI:109404
RefSeq - XM_006507897
RefSeq - NM_001287164
RefSeq - NM_001287165
RefSeq - NM_001287166
RefSeq - NM_001287167
RefSeq - NM_022979
RefSeq - XM_006507895
RefSeq - XM_006507896
RefSeq Peptide - NP_001274096
RefSeq Peptide - NP_075355
RefSeq Peptide - NP_001274093
RefSeq Peptide - NP_001274094
RefSeq Peptide - NP_001274095
swissprot - A0A1B0GS62
swissprot - A0A1B0GRB5
swissprot - A0A1B0GRA7
swissprot - B2RQL0
swissprot - A0A140T8J8
swissprot - A0A1B0GSX7
Ensembl - ENSMUSG00000063550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nup98ENSDARG00000074955Danio rerio
 NUP98ENSGALG00000040018Gallus gallus
 NUP98ENSG00000110713Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007230  Peptidase S59, nucleoporin
 IPR021967  Nuclear protein 96
 IPR025574  Nucleoporin FG repeat
 IPR036903  Peptidase S59, nucleoporin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:0051292 nuclear pore complex assembly IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031080 nuclear pore outer ring IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034399 nuclear periphery IEA
 cellular_componentGO:0042405 nuclear inclusion body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044615 nuclear pore nuclear basket IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding IEA
 molecular_functionGO:0017056 structural constituent of nuclear pore IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Transport of Mature mRNA derived from an Intron-Containing Transcript
Regulation of Glucokinase by Glucokinase Regulatory Protein
snRNP Assembly
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001839 abnormal level of surface class I molecules "deviation from the normal concentration of major histocompatibility complex class I molecules expressed at the cell surface " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005040 abnormal MHC II cell surface expression on macrophages "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31326]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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