Manteia

ENSMUSG00000063796

Mus musculus

Features

Gene ID:	ENSMUSG00000063796

Biological name :	Slc22a8

Synonyms :	O88909 / Slc22a8 / Solute carrier family 22 member 8

Possible biological names infered from orthology :	Q8TCC7

Species:	Mus musculus

Chr. number:	19
Strand:	1
Band:	A
Gene start:	8591254
Gene end:	8611834

Corresponding Affymetrix probe sets:	10461115 (MoGene1.0st) 1416966_at (Mouse Genome 430 2.0 Array) 1435418_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000010251 Ensembl peptide - ENSMUSP00000131045 NCBI entrez gene - 19879 See in Manteia. MGI - MGI:1336187 RefSeq - XM_011247171 RefSeq - NM_001164634 RefSeq - NM_001164635 RefSeq - NM_031194 RefSeq - XM_006526787 RefSeq Peptide - NP_112471 RefSeq Peptide - NP_001158106 RefSeq Peptide - NP_001158107 swissprot - O88909 Ensembl - ENSMUSG00000063796

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
oatx	ENSDARG00000019713	Danio rerio
slc22a6l	ENSDARG00000055523	Danio rerio
Q8TCC7	ENSG00000149452	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q8VC69 / Slc22a6 / Solute carrier family 22 member 6 / Q4U2R8*	ENSMUSG00000024650	48
Q80UJ1 / Slc22a20 / Solute carrier family 22 member 20	ENSMUSG00000037451	46
Slc22a12 / solute carrier family 22 member 12 / Q96S37*	ENSMUSG00000061742	44
Q8R0S9 / Slc22a22 / Mus musculus solute carrier family 22 (organic cation transporter), member 22 (Slc22a22), transcript variant 2, mRNA.	ENSMUSG00000022366	38
Q8VCA0 / Slc22a19 / Solute carrier family 22 member 19 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*	ENSMUSG00000024757	36
Slc22a29 / solute carrier family 22. member 29 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*	ENSMUSG00000075044	36
Slc22a30 / solute carrier family 22, member 30 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*	ENSMUSG00000052562	36
Slc22a28 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*	ENSMUSG00000063590	35
Q76M72 / Slc22a27 / Solute carrier family 22 member 27 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*	ENSMUSG00000067656	35
Slc22a26 / solute carrier family 22 (organic cation transporter), member 26 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*	ENSMUSG00000053303	35
Slc22a7 / solute carrier family 22 member 7 / Q9Y694*	ENSMUSG00000067144	34
Q6A4L0 / Slc22a13 / Solute carrier family 22 member 13 / Q9Y226*	ENSMUSG00000074028	34
O08966 / Slc22a1 / Solute carrier family 22 member 1 / O15245*	ENSMUSG00000023829	31
O70577 / Slc22a2 / Solute carrier family 22 member 2 / O15244*	ENSMUSG00000040966	31
Q9Z0E8 / Slc22a5 / solute carrier family 22 (organic cation transporter), member 5 / O76082* / solute carrier family 22 member 5*	ENSMUSG00000018900	30
Q9Z306 / Slc22a4 / Solute carrier family 22 member 4 / Q9H015*	ENSMUSG00000020334	30
Q9WTN6 / Slc22a21 / solute carrier family 22 (organic cation transporter), member 21 / O76082* / SLC22A5* / solute carrier family 22 member 5*	ENSMUSG00000063652	29
Q9WTW5 / Slc22a3 / solute carrier family 22 (organic cation transporter), member 3 / O75751* / solute carrier family 22 member 3*	ENSMUSG00000023828	29
Q504N2 / Slc22a15 / Solute carrier family 22 member 15 / Q8IZD6*	ENSMUSG00000033147	29
Slc22a14 / solute carrier family 22 (organic cation transporter), member 14 / Q9Y267* / solute carrier family 22 member 14*	ENSMUSG00000070280	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR004749	Organic cation transport protein/SVOP
IPR005828	Major facilitator, sugar transporter-like
IPR020846	Major facilitator superfamily domain
IPR036259	MFS transporter superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0009636	response to toxic substance	IEA
biological_process	GO:0015698	inorganic anion transport	IEA
biological_process	GO:0043252	sodium-independent organic anion transport	IBA
biological_process	GO:0055085	transmembrane transport	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0016323	basolateral plasma membrane	IEA
molecular_function	GO:0005452	inorganic anion exchanger activity	ISO
molecular_function	GO:0015347	sodium-independent organic anion transmembrane transporter activity	IBA
molecular_function	GO:0022857	transmembrane transporter activity	IEA

Pathways (from Reactome)

Pathway description

Organic anion transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
MP:0006272	abnormal renal organic anion excretion	"anomaly in the ability of the kidneys to elimiate organic acids (represented by the prototypical substrate para-aminohippurate (PAH))" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:108655]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011424	decreased urine uric acid level	"abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:anna]	Show Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn,Vdr^tm1Mbd/Vdr^tm1Mbd Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr