ENSMUSG00000024650


Mus musculus

Features
Gene ID: ENSMUSG00000024650
  
Biological name :Slc22a6
  
Synonyms : Q8VC69 / Slc22a6 / Solute carrier family 22 member 6
  
Possible biological names infered from orthology : Q4U2R8
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 8617996
Gene end: 8628299
  
Corresponding Affymetrix probe sets: 10461130 (MoGene1.0st)   1417072_at (Mouse Genome 430 2.0 Array)   1438332_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010250
NCBI entrez gene - 18399     See in Manteia.
MGI - MGI:892001
RefSeq - NM_008766
RefSeq Peptide - NP_032792
swissprot - Q8VC69
Ensembl - ENSMUSG00000024650
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oatxENSDARG00000019713Danio rerio
 slc22a6lENSDARG00000055523Danio rerio
 Q4U2R8ENSG00000197901Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O88909 / Slc22a8 / Solute carrier family 22 member 8 / Q8TCC7*ENSMUSG0000006379648
Q80UJ1 / Slc22a20 / Solute carrier family 22 member 20 ENSMUSG0000003745146
Slc22a12 / solute carrier family 22 member 12 / Q96S37*ENSMUSG0000006174243
Slc22a26 / solute carrier family 22 (organic cation transporter), member 26 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005330337
Q8VCA0 / Slc22a19 / Solute carrier family 22 member 19 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000002475737
Slc22a28 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006359036
Slc22a30 / solute carrier family 22, member 30 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005256236
Q76M72 / Slc22a27 / Solute carrier family 22 member 27 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006765635
Slc22a7 / solute carrier family 22 member 7 / Q9Y694*ENSMUSG0000006714435
Slc22a29 / solute carrier family 22. member 29 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000007504434
Q6A4L0 / Slc22a13 / Solute carrier family 22 member 13 / Q9Y226*ENSMUSG0000007402834
Q8R0S9 / Slc22a22 / Mus musculus solute carrier family 22 (organic cation transporter), member 22 (Slc22a22), transcript variant 2, mRNA.ENSMUSG0000002236633
O08966 / Slc22a1 / Solute carrier family 22 member 1 / O15245*ENSMUSG0000002382933
O70577 / Slc22a2 / Solute carrier family 22 member 2 / O15244*ENSMUSG0000004096632
Q9WTW5 / Slc22a3 / solute carrier family 22 (organic cation transporter), member 3 / O75751* / solute carrier family 22 member 3*ENSMUSG0000002382830
Q9WTN6 / Slc22a21 / solute carrier family 22 (organic cation transporter), member 21 / O76082* / SLC22A5* / solute carrier family 22 member 5*ENSMUSG0000006365229
Q9Z0E8 / Slc22a5 / solute carrier family 22 (organic cation transporter), member 5 / O76082* / solute carrier family 22 member 5*ENSMUSG0000001890029
Q9Z306 / Slc22a4 / Solute carrier family 22 member 4 / Q9H015*ENSMUSG0000002033428
Q504N2 / Slc22a15 / Solute carrier family 22 member 15 / Q8IZD6*ENSMUSG0000003314727
Slc22a14 / solute carrier family 22 (organic cation transporter), member 14 / Q9Y267* / solute carrier family 22 member 14*ENSMUSG0000007028026


Protein motifs (from Interpro)
Interpro ID Name
 IPR004749  Organic cation transport protein/SVOP
 IPR005828  Major facilitator, sugar transporter-like
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006820 anion transport IDA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0015711 organic anion transport IEA
 biological_processGO:0015742 alpha-ketoglutarate transport IEA
 biological_processGO:0015747 urate transport IBA
 biological_processGO:0031427 response to methotrexate IEA
 biological_processGO:0043252 sodium-independent organic anion transport IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0097254 renal tubular secretion IMP
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0005452 inorganic anion exchanger activity IEA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IEA
 molecular_functionGO:0015143 urate transmembrane transporter activity IBA
 molecular_functionGO:0015301 anion:anion antiporter activity IEA
 molecular_functionGO:0015347 sodium-independent organic anion transmembrane transporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0031404 chloride ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Organic anion transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006272 abnormal renal organic anion excretion "anomaly in the ability of the kidneys to elimiate organic acids (represented by the prototypical substrate para-aminohippurate (PAH))" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:108655]
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Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0011424 decreased urine uric acid level "abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:anna]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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