ENSMUSG00000018900


Mus musculus

Features
Gene ID: ENSMUSG00000018900
  
Biological name :Slc22a5
  
Synonyms : Q9Z0E8 / Slc22a5 / solute carrier family 22 (organic cation transporter), member 5
  
Possible biological names infered from orthology : O76082 / solute carrier family 22 member 5
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 53864542
Gene end: 53891660
  
Corresponding Affymetrix probe sets: 10385872 (MoGene1.0st)   1421848_at (Mouse Genome 430 2.0 Array)   1450395_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019044
Ensembl peptide - ENSMUSP00000115474
Ensembl peptide - ENSMUSP00000118900
NCBI entrez gene - 20520     See in Manteia.
MGI - MGI:1329012
RefSeq - XM_017314397
RefSeq - NM_011396
RefSeq - XM_006532650
RefSeq - XM_006532651
RefSeq - XM_006532652
RefSeq Peptide - NP_035526
swissprot - Q9Z0E8
swissprot - F6TNN8
swissprot - D6RH54
swissprot - Q5SX17
Ensembl - ENSMUSG00000018900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc22a21ENSDARG00000094112Danio rerio
 slc22a4ENSDARG00000005335Danio rerio
 slc22a5ENSDARG00000101021Danio rerio
 SLC22A5ENSGALG00000036920Gallus gallus
 O76082ENSG00000197375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WTN6 / Slc22a21 / solute carrier family 22 (organic cation transporter), member 21 / O76082* / SLC22A5* / solute carrier family 22 member 5*ENSMUSG0000006365284
Q9Z306 / Slc22a4 / Solute carrier family 22 member 4 / Q9H015*ENSMUSG0000002033475
O08966 / Slc22a1 / Solute carrier family 22 member 1 / O15245*ENSMUSG0000002382931
Slc22a7 / solute carrier family 22 member 7 / Q9Y694*ENSMUSG0000006714431
Q80UJ1 / Slc22a20 / Solute carrier family 22 member 20 ENSMUSG0000003745131
O70577 / Slc22a2 / Solute carrier family 22 member 2 / O15244*ENSMUSG0000004096631
Slc22a26 / solute carrier family 22 (organic cation transporter), member 26 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005330329
O88909 / Slc22a8 / Solute carrier family 22 member 8 / Q8TCC7*ENSMUSG0000006379629
Q9WTW5 / Slc22a3 / solute carrier family 22 (organic cation transporter), member 3 / O75751* / solute carrier family 22 member 3*ENSMUSG0000002382829
Q6A4L0 / Slc22a13 / Solute carrier family 22 member 13 / Q9Y226*ENSMUSG0000007402829
Q8R0S9 / Slc22a22 / Mus musculus solute carrier family 22 (organic cation transporter), member 22 (Slc22a22), transcript variant 2, mRNA.ENSMUSG0000002236629
Slc22a12 / solute carrier family 22 member 12 / Q96S37*ENSMUSG0000006174228
Slc22a30 / solute carrier family 22, member 30 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005256228
Q8VC69 / Slc22a6 / Solute carrier family 22 member 6 / Q4U2R8*ENSMUSG0000002465028
Q504N2 / Slc22a15 / Solute carrier family 22 member 15 / Q8IZD6*ENSMUSG0000003314728
Slc22a28 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006359028
Slc22a29 / solute carrier family 22. member 29 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000007504427
Q76M72 / Slc22a27 / Solute carrier family 22 member 27 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006765627
Q8VCA0 / Slc22a19 / Solute carrier family 22 member 19 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000002475726
Q497L8 / Slc22a16 / solute carrier family 22 (organic cation transporter), member 16 / Q86VW1* / solute carrier family 22 member 16*ENSMUSG0000001983426


Protein motifs (from Interpro)
Interpro ID Name
 IPR004749  Organic cation transport protein/SVOP
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007512 adult heart development IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0009437 carnitine metabolic process IMP
 biological_processGO:0015697 quaternary ammonium group transport ISO
 biological_processGO:0015711 organic anion transport IEA
 biological_processGO:0015879 carnitine transport ISO
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0048608 reproductive structure development IMP
 biological_processGO:0052106 quorum sensing involved in interaction with host ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060731 positive regulation of intestinal epithelial structure maintenance ISO
 biological_processGO:0070715 sodium-dependent organic cation transport ISO
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1902603 carnitine transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IBA
 molecular_functionGO:0015226 carnitine transmembrane transporter activity ISO
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015491 cation:cation antiporter activity IBA
 molecular_functionGO:0015651 quaternary ammonium group transmembrane transporter activity ISO
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0030165 PDZ domain binding ISO


Pathways (from Reactome)
Pathway description
Import of palmitoyl-CoA into the mitochondrial matrix
Organic cation transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002661 abnormal corpus "anomalous structure of the body of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003978 decreased circulating carnitine level "lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004928 increased epididymis weight "increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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