ENSMUSG00000063804


Mus musculus

Features
Gene ID: ENSMUSG00000063804
  
Biological name :Lin28b
  
Synonyms : B / Lin28b / Q45KJ6
  
Possible biological names infered from orthology : lin-28 homolog B / Q6ZN17
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B2
Gene start: 45376620
Gene end: 45486395
  
Corresponding Affymetrix probe sets: 10368981 (MoGene1.0st)   1430803_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078361
NCBI entrez gene - 380669     See in Manteia.
MGI - MGI:3584032
RefSeq - XM_011243188
RefSeq - NM_001031772
RefSeq - XM_011243186
RefSeq - XM_011243187
RefSeq - XM_011243180
RefSeq - XM_011243182
RefSeq - XM_011243183
RefSeq - XM_011243185
RefSeq Peptide - NP_001026942
swissprot - Q45KJ6
Ensembl - ENSMUSG00000063804
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lin28bENSDARG00000052511Danio rerio
 LIN28BENSGALG00000026761Gallus gallus
 LIN28BENSG00000187772Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A / Lin28a / Q8K3Y3 / Q9H9Z2* / lin-28 homolog A*ENSMUSG0000005096650


Protein motifs (from Interpro)
Interpro ID Name
 IPR001878  Zinc finger, CCHC-type
 IPR002059  Cold-shock protein, DNA-binding
 IPR011129  Cold shock domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010587 miRNA catabolic process IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0031123 RNA 3"-end processing IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pdgfratm11(EGFP)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Lin28btm1Gqda/Lin28btm1.1Gqda,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Lin28btm1Gqda/Lin28btm1Gqda,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

Allelic Composition: Lin28atm2.1Gqda/Lin28atm2.1Gqda,Lin28btm2.1Gqda/Lin28btm2.1Gqda
Genetic Background: STOCK Lin28atm2.1Gqda Lin28btm2.1Gqda/J

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lin28btm1Gqda/Lin28btm1Gqda,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lin28btm1Gqda/Lin28btm1Gqda,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010507 shortened RR interval "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0012681 collapsed brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord are severely reduced in volume or area, possibly due to reduced or absent cerebrospinal fluid production; collapsed ventricles can be a sign of increased intracranial pressure and accumulation of water in the brain parenchyma" [MGI:anna]
Show

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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