ENSMUSG00000050966


Mus musculus

Features
Gene ID: ENSMUSG00000050966
  
Biological name :Lin28a
  
Synonyms : A / Lin28a / Q8K3Y3
  
Possible biological names infered from orthology : lin-28 homolog A / Q9H9Z2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 134003330
Gene end: 134018841
  
Corresponding Affymetrix probe sets: 10517159 (MoGene1.0st)   1437752_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050488
Ensembl peptide - ENSMUSP00000135254
Ensembl peptide - ENSMUSP00000135608
Ensembl peptide - ENSMUSP00000135736
NCBI entrez gene - 83557     See in Manteia.
MGI - MGI:1890546
RefSeq - XM_011250361
RefSeq - NM_145833
RefSeq Peptide - NP_665832
swissprot - H3BL11
swissprot - H3BK51
swissprot - Q8K3Y3
swissprot - H3BLC6
Ensembl - ENSMUSG00000050966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIN28AENSDARG00000004328Danio rerio
 LIN28AENSGALG00000036022Gallus gallus
 LIN28AENSG00000131914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B / Lin28b / Q45KJ6 / Q6ZN17* / lin-28 homolog B*ENSMUSG0000006380465


Protein motifs (from Interpro)
Interpro ID Name
 IPR001878  Zinc finger, CCHC-type
 IPR002059  Cold-shock protein, DNA-binding
 IPR011129  Cold shock domain
 IPR012156  Cold shock, CspA
 IPR012340  Nucleic acid-binding, OB-fold
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0010586 miRNA metabolic process IDA
 biological_processGO:0010587 miRNA catabolic process IEA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0031123 RNA 3"-end processing IEA
 biological_processGO:0032008 positive regulation of TOR signaling IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045686 negative regulation of glial cell differentiation IDA
 biological_processGO:0045727 positive regulation of translation IDA
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060964 regulation of gene silencing by miRNA IGI
 biological_processGO:0071333 cellular response to glucose stimulus IMP
 biological_processGO:1901724 positive regulation of cell proliferation involved in kidney development IMP
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IDA
 biological_processGO:2000767 positive regulation of cytoplasmic translation IEA
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0010494 cytoplasmic stress granule ISS
 molecular_functionGO:0002151 G-quadruplex RNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031369 translation initiation factor binding IPI
 molecular_functionGO:0035198 miRNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1905538 polysome binding IEA
 molecular_functionGO:1990825 sequence-specific mRNA binding IDA


Pathways (from Reactome)
Pathway description
Transcriptional regulation of pluripotent stem cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1.1Gqda,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Lin28atm1Gqda/Lin28atm1.1Gqda,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda,Tsc1tm1.1Djk/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

Allelic Composition: Lin28atm2.1Gqda/Lin28atm2.1Gqda,Lin28btm2.1Gqda/Lin28btm2.1Gqda
Genetic Background: STOCK Lin28atm2.1Gqda Lin28btm2.1Gqda/J

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda,Tsc1tm1.1Djk/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0011121 decreased primordial ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

 MP:0012681 collapsed brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord are severely reduced in volume or area, possibly due to reduced or absent cerebrospinal fluid production; collapsed ventricles can be a sign of increased intracranial pressure and accumulation of water in the brain parenchyma" [MGI:anna]
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Allelic Composition: Lin28atm1.1Gqda/Lin28a+,Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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