ENSG00000131914


Homo sapiens

Features
Gene ID: ENSG00000131914
  
Biological name :LIN28A
  
Synonyms : LIN28A / lin-28 homolog A / Q9H9Z2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.11
Gene start: 26410778
Gene end: 26429722
  
Corresponding Affymetrix probe sets: 219823_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254231
Ensembl peptide - ENSP00000363314
NCBI entrez gene - 79727     See in Manteia.
OMIM - 611043
RefSeq - XM_011542148
RefSeq - NM_024674
RefSeq Peptide - NP_078950
swissprot - Q9H9Z2
Ensembl - ENSG00000131914
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIN28AENSDARG00000004328Danio rerio
 LIN28AENSGALG00000036022Gallus gallus
 A ENSMUSG00000050966Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LIN28B / Q6ZN17 / lin-28 homolog BENSG0000018777264


Protein motifs (from Interpro)
Interpro ID Name
 IPR001878  Zinc finger, CCHC-type
 IPR002059  Cold-shock protein, DNA-binding
 IPR011129  Cold shock domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0010586 miRNA metabolic process IEA
 biological_processGO:0010587 miRNA catabolic process IMP
 biological_processGO:0017148 negative regulation of translation ISS
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IMP
 biological_processGO:0031123 RNA 3"-end processing IMP
 biological_processGO:0032008 positive regulation of TOR signaling ISS
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045686 negative regulation of glial cell differentiation IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 biological_processGO:0060964 regulation of gene silencing by miRNA IEA
 biological_processGO:0071333 cellular response to glucose stimulus ISS
 biological_processGO:1901724 positive regulation of cell proliferation involved in kidney development IEA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA ISS
 biological_processGO:2000767 positive regulation of cytoplasmic translation IMP
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 molecular_functionGO:0002151 G-quadruplex RNA binding ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031369 translation initiation factor binding IEA
 molecular_functionGO:0035198 miRNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1905538 polysome binding IDA
 molecular_functionGO:1990825 sequence-specific mRNA binding ISS


Pathways (from Reactome)
Pathway description
Transcriptional regulation of pluripotent stem cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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