ENSMUSG00000066456


Mus musculus

Features
Gene ID: ENSMUSG00000066456
  
Biological name :Hmgn3
  
Synonyms : High mobility group nucleosome-binding domain-containing protein 3 / Hmgn3 / Q9DCB1
  
Possible biological names infered from orthology : high mobility group nucleosomal binding domain 3 / Q15651
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E2
Gene start: 83109948
Gene end: 83146685
  
Corresponding Affymetrix probe sets: 10595371 (MoGene1.0st)   1431777_a_at (Mouse Genome 430 2.0 Array)   1434875_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140980
Ensembl peptide - ENSMUSP00000124278
Ensembl peptide - ENSMUSP00000125616
Ensembl peptide - ENSMUSP00000140247
Ensembl peptide - ENSMUSP00000140356
NCBI entrez gene - 94353     See in Manteia.
MGI - MGI:2138069
RefSeq - XM_006511591
RefSeq - XM_006511590
RefSeq - NM_175074
RefSeq - NM_026122
RefSeq Peptide - NP_778249
RefSeq Peptide - NP_080398
swissprot - Q9DCB1
swissprot - A0A087WSB8
Ensembl - ENSMUSG00000066456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgn3ENSDARG00000036754Danio rerio
 HMGN3ENSGALG00000015880Gallus gallus
 HMGN3ENSG00000118418Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000079  High mobility group protein HMGN
 IPR031073  High mobility group protein HMGN3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0031492 nucleosomal DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-p/Tyrc
Genetic Background: Not Specified

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tyrc-p/Tyrc
Genetic Background: Not Specified

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Tyrc-p/Tyrc
Genetic Background: Not Specified

Allelic Composition: Hmgn3tm1.2Mbus/Hmgn3tm1.2Mbus
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgn3tm1.2Mbus/Hmgn3tm1.2Mbus
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Hmgn3tm1.2Mbus/Hmgn3tm1.2Mbus
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgn3tm1.2Mbus/Hmgn3tm1.2Mbus
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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