ENSMUSG00000066900


Mus musculus

Features
Gene ID: ENSMUSG00000066900
  
Biological name :Suds3
  
Synonyms : Q8BR65 / Sin3 histone deacetylase corepressor complex component SDS3 / Suds3
  
Possible biological names infered from orthology : Q9H7L9 / SDS3 homolog, SIN3A corepressor complex component
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 117091680
Gene end: 117116113
  
Corresponding Affymetrix probe sets: 10533071 (MoGene1.0st)   1427896_at (Mouse Genome 430 2.0 Array)   1427897_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083662
Ensembl peptide - ENSMUSP00000130535
NCBI entrez gene - 71954     See in Manteia.
MGI - MGI:1919204
RefSeq - NM_001122666
RefSeq - NM_178622
RefSeq Peptide - NP_001116138
RefSeq Peptide - NP_848737
swissprot - Q8BR65
swissprot - A0A0R4J243
Ensembl - ENSMUSG00000066900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 suds3ENSDARG00000073737Danio rerio
 SUDS3ENSGALG00000007393Gallus gallus
 SUDS3ENSG00000111707Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013907  Sds3-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016580 Sin3 complex IDA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IDA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Suds3tm1.1Rdp/Suds3+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Suds3tm1.1Rdp/Suds3+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs,Trp53tm1Sia/Trp53+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs,Trp53tm1Sia/Trp53+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Suds3tm1.1Rdp/Suds3+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB

Allelic Composition: Suds3tm1Rdp/Suds3tm1Rdp
Genetic Background: involves: 129S6/SvEvTac

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Suds3tm1Rdp/Suds3tm1Rdp
Genetic Background: involves: 129S6/SvEvTac

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Suds3tm1.1Rdp/Suds3+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs/Ryr2tm1(CAG-KRAS*G12V,-lacZ)Nobs,Trp53tm1Sia/Trp53+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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