ENSMUSG00000068220


Mus musculus

Features
Gene ID: ENSMUSG00000068220
  
Biological name :Lgals1
  
Synonyms : Galectin-1 / Lgals1 / P16045
  
Possible biological names infered from orthology : P09382
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 78926725
Gene end: 78930465
  
Corresponding Affymetrix probe sets: 10425161 (MoGene1.0st)   1419573_a_at (Mouse Genome 430 2.0 Array)   1455439_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086795
Ensembl peptide - ENSMUSP00000155144
NCBI entrez gene - 16852     See in Manteia.
MGI - MGI:96777
RefSeq - NM_008495
RefSeq Peptide - NP_032521
swissprot - P16045
Ensembl - ENSMUSG00000068220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgals1l1ENSDARG00000088711Danio rerio
 lgals2aENSDARG00000054942Danio rerio
 lgals2bENSDARG00000038153Danio rerio
 LGALS1ENSGALG00000012420Gallus gallus
 LGALS1ENSG00000100097Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lgals2 / Q9CQW5 / Galectin-2 / P05162*ENSMUSG0000004350141


Protein motifs (from Interpro)
Interpro ID Name
 IPR001079  Galectin, carbohydrate recognition domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002317 plasma cell differentiation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules NAS
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0034120 positive regulation of erythrocyte aggregation IEA
 biological_processGO:0035900 response to isolation stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045445 myoblast differentiation IDA
 biological_processGO:0046598 positive regulation of viral entry into host cell IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005534 galactose binding NAS
 molecular_functionGO:0030246 carbohydrate binding IDA
 molecular_functionGO:0030395 lactose binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043236 laminin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000736 delayed muscle development "late onset of the induction and/or differentiation of skeletal muscle" [J:18048]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0000969 abnormal nociceptor morphology "anomalous structure of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0000972 abnormal mechanoreceptor morphology "anomaly in the receptors of the body, usually nerve termini, that respond to mechanical pressure or distortion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:34172]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: B6.129P2-Il18tm1Aki

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0005236 abnormal olfactory nerve morphology "anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rbl1tm1Tyj/Rbl1tm1Tyj,Rbl2tm1Tyj/Rbl2tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: at/at
Genetic Background: Not Specified

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr