ENSMUSG00000068267


Mus musculus

Features
Gene ID: ENSMUSG00000068267
  
Biological name :Cenpb
  
Synonyms : Cenpb / Major centromere autoantigen B / P27790
  
Possible biological names infered from orthology : centromere protein B / P07199
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 131175182
Gene end: 131180067
  
Corresponding Affymetrix probe sets: 10487871 (MoGene1.0st)   1426051_a_at (Mouse Genome 430 2.0 Array)   1435944_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086938
NCBI entrez gene - 12616     See in Manteia.
MGI - MGI:88376
RefSeq - NM_007682
RefSeq Peptide - NP_031708
swissprot - P27790
Ensembl - ENSMUSG00000068267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CENPBENSG00000125817Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tigd4 / Q8BUZ3 / Tigger transposable element-derived protein 4 / Q8IY51* / tigger transposable element derived 4*ENSMUSG0000004781923
Tigd3 / Q7TM95 / Tigger transposable element-derived protein 3 / Q6B0B8* / tigger transposable element derived 3*ENSMUSG0000004439020
Tigd2 / Q0VBL1 / Tigger transposable element-derived protein 2 / Q4W5G0* / tigger transposable element derived 2*ENSMUSG0000004923218
Jrkl / B2RRL2 / Jerky protein homolog-like / Q9Y4A0* / JRK like*ENSMUSG0000007908318
Tigd5 / Q499M4 / Tigger transposable element derived 5 / Q53EQ6*ENSMUSG0000010390618
Jrk / Q60976 / Jerky protein / Jrk helix-turn-helix protein*ENSMUSG0000004638017


Protein motifs (from Interpro)
Interpro ID Name
 IPR004875  DDE superfamily endonuclease domain
 IPR006600  HTH CenpB-type DNA-binding domain
 IPR007889  DNA binding HTH domain, Psq-type
 IPR009057  Homeobox-like domain superfamily
 IPR015115  Centromere protein CENP-B, C-terminal domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR033062  Major centromere autoantigen B
 IPR034882  CENP-B, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome ISO
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031618 nuclear pericentric heterochromatin IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003696 satellite DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0001121 uterine hypoplasia "reduced size of the uterus due to decreased cell number" [J:45065]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx2tm1Pa/Tbx2tm1Pa
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Cenpbtm1Gmay/Cenpbtm1Gmay
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002292 abnormal gestational length "anomaly in the usual duration of time between when a fertilized egg implants in the wall of the uterus and the birth of offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0009096 decreased endometrial gland number "fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0012008 delayed parturition "the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated" [MGI:csmith]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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