ENSMUSG00000068882


Mus musculus

Features
Gene ID: ENSMUSG00000068882
  
Biological name :Ssb
  
Synonyms : P32067 / Sjogren syndrome antigen B / Ssb
  
Possible biological names infered from orthology : P05455
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 69861562
Gene end: 69871846
  
Corresponding Affymetrix probe sets: 10472605 (MoGene1.0st)   1416421_a_at (Mouse Genome 430 2.0 Array)   1416422_a_at (Mouse Genome 430 2.0 Array)   1416423_x_at (Mouse Genome 430 2.0 Array)   1453928_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119773
Ensembl peptide - ENSMUSP00000130313
Ensembl peptide - ENSMUSP00000088365
Ensembl peptide - ENSMUSP00000107879
Ensembl peptide - ENSMUSP00000115666
NCBI entrez gene - 20823     See in Manteia.
MGI - MGI:98423
RefSeq - NM_001355265
RefSeq - XM_006499069
RefSeq - NM_009278
RefSeq - NM_001110145
RefSeq Peptide - NP_001103615
RefSeq Peptide - NP_001342194
RefSeq Peptide - NP_033304
swissprot - Q564E6
swissprot - F6SXM5
swissprot - P32067
swissprot - A2AR07
swissprot - D6RI87
Ensembl - ENSMUSG00000068882
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ssbENSDARG00000029252Danio rerio
 SSBENSGALG00000009677Gallus gallus
 SSBENSG00000138385Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002344  Lupus La protein
 IPR006630  La-type HTH domain
 IPR014886  La protein, RNA-binding domain
 IPR035979  RNA-binding domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001682 tRNA 5"-leader removal IEA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006409 tRNA export from nucleus IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0042780 tRNA 3"-end processing IEA
 biological_processGO:0071045 nuclear histone mRNA catabolic process IEA
 biological_processGO:0075522 IRES-dependent viral translational initiation IEA
 biological_processGO:1903608 protein localization to cytoplasmic stress granule IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0008266 poly(U) RNA binding IEA
 molecular_functionGO:1990825 sequence-specific mRNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0010014 hippocampus pyramidal cell degeneration "a retrogressive impairment or destruction of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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