ENSMUSG00000069844


Mus musculus

Features
Gene ID: ENSMUSG00000069844
  
Biological name :Sco1
  
Synonyms : , mitochondrial / Q5SUC9 / Sco1
  
Possible biological names infered from orthology : O75880 / SCO1, cytochrome c oxidase assembly protein
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 67052670
Gene end: 67067070
  
Corresponding Affymetrix probe sets: 10377010 (MoGene1.0st)   1430300_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090673
Ensembl peptide - ENSMUSP00000104330
NCBI entrez gene - 52892     See in Manteia.
MGI - MGI:106362
RefSeq - XM_006533721
RefSeq - NM_001040026
RefSeq Peptide - NP_001035115
swissprot - Q5SUC9
swissprot - Q5SUD5
Ensembl - ENSMUSG00000069844
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sco1ENSDARG00000067593Danio rerio
 SCO1ENSGALG00000030475Gallus gallus
 SCO1ENSG00000133028Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sco2 / Q8VCL2 / , mitochondrial / O43819* / SCO2, cytochrome c oxidase assembly protein*ENSMUSG0000009178037


Protein motifs (from Interpro)
Interpro ID Name
 IPR003782  Copper chaperone SCO1/SenC
 IPR013766  Thioredoxin domain
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006878 cellular copper ion homeostasis IMP
 biological_processGO:0033617 mitochondrial respiratory chain complex IV assembly IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0030016 myofibril IEA
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane IEA
 cellular_componentGO:0072492 host cell mitochondrial intermembrane space IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Glultm1.1Geno/Glultm1.1Geno,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0003067 decreased hepatic copper content "a reduced amount of copper in the liver tissue compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0010244 decreased kidney copper level "a reduced amount of copper in the kidney tissue compared to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0011628 increased mitochondria number "greater than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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