ENSMUSG00000091780


Mus musculus

Features
Gene ID: ENSMUSG00000091780
  
Biological name :Sco2
  
Synonyms : , mitochondrial / Q8VCL2 / Sco2
  
Possible biological names infered from orthology : O43819 / SCO2, cytochrome c oxidase assembly protein
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 89371637
Gene end: 89373846
  
Corresponding Affymetrix probe sets: 1432181_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131943
Ensembl peptide - ENSMUSP00000155150
NCBI entrez gene - 100126824     See in Manteia.
MGI - MGI:3818630
RefSeq - NM_001111288
RefSeq Peptide - NP_001104758
swissprot - Q8VCL2
Ensembl - ENSMUSG00000091780
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sco2ENSDARG00000045555Danio rerio
 SCO2ENSG00000284194Homo sapiens
 SCO2ENSG00000130489Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sco1 / Q5SUC9 / , mitochondrial / O75880* / SCO1, cytochrome c oxidase assembly protein*ENSMUSG0000006984441


Protein motifs (from Interpro)
Interpro ID Name
 IPR003782  Copper chaperone SCO1/SenC
 IPR013766  Thioredoxin domain
 IPR017276  Synthesis of cytochrome c oxidase, Sco1/Sco2
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development ISS
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0003012 muscle system process IMP
 biological_processGO:0006825 copper ion transport IEA
 biological_processGO:0006878 cellular copper ion homeostasis IEA
 biological_processGO:0008535 respiratory chain complex IV assembly IEA
 biological_processGO:0014823 response to activity IMP
 biological_processGO:0022904 respiratory electron transport chain IMP
 biological_processGO:0033617 mitochondrial respiratory chain complex IV assembly ISS
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055070 copper ion homeostasis IMP
 biological_processGO:0097034 obsolete mitochondrial respiratory chain complex IV biogenesis ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0030016 myofibril ISO
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane ISS
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1.1Lahe/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL

Allelic Composition: Sco2tm1.1Easc/Sco2tm2.1Easc
Genetic Background: 129X1/SvJ-Sco2tm1.1Easc/Sco2tm2.1Easc

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1.1Lahe/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1.1Lahe/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL

 MP:0003066 increased hepatic copper content "a greater accumulation of copper in the liver tissue compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sco2tm1.1Easc/Sco2tm2.1Easc
Genetic Background: 129X1/SvJ-Sco2tm1.1Easc/Sco2tm2.1Easc

 MP:0003952 abnormal copper level "anomaly in the concentration in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wt1tm1.1Lahe/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL

Allelic Composition: Sco2tm1.1Easc/Sco2tm2.1Easc
Genetic Background: 129X1/SvJ-Sco2tm1.1Easc/Sco2tm2.1Easc

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wt1tm1.1Lahe/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL

Allelic Composition: Sco2tm1.1Easc/Sco2tm2.1Easc
Genetic Background: 129X1/SvJ-Sco2tm1.1Easc/Sco2tm2.1Easc

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Wt1tm1.1Lahe/Wt1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Sco2tm1.1Easc/Sco2tm2.1Easc
Genetic Background: 129X1/SvJ-Sco2tm1.1Easc/Sco2tm2.1Easc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr