ENSMUSG00000071337


Mus musculus

Features
Gene ID: ENSMUSG00000071337
  
Biological name :Tia1
  
Synonyms : cytotoxic granule-associated RNA binding protein 1 / P52912 / Tia1
  
Possible biological names infered from orthology : P31483 / TIA1 cytotoxic granule associated RNA binding protein
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 86404219
Gene end: 86433405
  
Corresponding Affymetrix probe sets: 10539710 (MoGene1.0st)   1416812_at (Mouse Genome 430 2.0 Array)   1416813_at (Mouse Genome 430 2.0 Array)   1416814_at (Mouse Genome 430 2.0 Array)   1431708_a_at (Mouse Genome 430 2.0 Array)   1437934_at (Mouse Genome 430 2.0 Array)   1453803_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118558
Ensembl peptide - ENSMUSP00000109342
Ensembl peptide - ENSMUSP00000138652
Ensembl peptide - ENSMUSP00000145407
Ensembl peptide - ENSMUSP00000145218
Ensembl peptide - ENSMUSP00000144857
Ensembl peptide - ENSMUSP00000093424
Ensembl peptide - ENSMUSP00000093425
Ensembl peptide - ENSMUSP00000093426
NCBI entrez gene - 21841     See in Manteia.
MGI - MGI:107914
RefSeq - XM_017321514
RefSeq - NM_001164078
RefSeq - NM_001164079
RefSeq - NM_011585
RefSeq - XM_006505889
RefSeq - XM_006505891
RefSeq - XM_006505893
RefSeq - XM_011241285
RefSeq - XM_011241286
RefSeq - XM_017321512
RefSeq - XM_017321513
RefSeq Peptide - NP_035715
RefSeq Peptide - NP_001157550
RefSeq Peptide - NP_001157551
swissprot - D3Z4H6
swissprot - D3YY02
swissprot - A0A0N4SW78
swissprot - G5E8L2
swissprot - A0A0N4SVR8
swissprot - Q80ZW7
swissprot - Q8CII5
swissprot - A0A0N4SUX1
swissprot - P52912
swissprot - Q564E7
Ensembl - ENSMUSG00000071337
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIA1ENSGALG00000013879Gallus gallus
 TIA1ENSG00000116001Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tial1 / P70318 / Tia1 cytotoxic granule-associated RNA binding protein-like 1 / Q01085*ENSMUSG0000003084676
Rbm42 / Q91V81 / RNA-binding protein 42 / Q9BTD8* / RNA binding motif protein 42*ENSMUSG0000003673318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR003954  RNA recognition motif domain, eukaryote
 IPR034827  TIA-1, RNA recognition motif 1
 IPR034830  TIA-1, RNA recognition motif 2
 IPR034832  TIA-1, RNA recognition motif 3
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0017148 negative regulation of translation IMP
 biological_processGO:0042036 negative regulation of cytokine biosynthetic process IMP
 biological_processGO:0048024 regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:1903608 protein localization to cytoplasmic stress granule IEA
 biological_processGO:1904037 positive regulation of epithelial cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0097165 nuclear stress granule IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IDA


Pathways (from Reactome)
Pathway description
FGFR2 alternative splicing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tia1tm1Andp/Tia1tm1Andp,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Tia1tm1Andp Zfp36tm1Pjb

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tial1tm1Mst/Tial1tm1Mst
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tial1tm1Mst/Tial1tm1Mst
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Tia1tm1Andp/Tia1tm1Andp,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Tia1tm1Andp Zfp36tm1Pjb

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tia1tm1Andp/Tia1tm1Andp,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Tia1tm1Andp Zfp36tm1Pjb

Allelic Composition: Tia1tm1Andp/Tia1tm1Andp
Genetic Background: B6.Cg-Tia1tm1Andp

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tial1tm1Mst/Tial1tm1Mst
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tial1tm1Mst/Tial1tm1Mst
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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