ENSMUSG00000030846


Mus musculus

Features
Gene ID: ENSMUSG00000030846
  
Biological name :Tial1
  
Synonyms : P70318 / Tia1 cytotoxic granule-associated RNA binding protein-like 1 / Tial1
  
Possible biological names infered from orthology : Q01085
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 128439777
Gene end: 128461717
  
Corresponding Affymetrix probe sets: 10568399 (MoGene1.0st)   1421148_a_at (Mouse Genome 430 2.0 Array)   1426352_s_at (Mouse Genome 430 2.0 Array)   1452821_at (Mouse Genome 430 2.0 Array)   1455675_a_at (Mouse Genome 430 2.0 Array)   1455676_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101835
Ensembl peptide - ENSMUSP00000146031
Ensembl peptide - ENSMUSP00000145943
Ensembl peptide - ENSMUSP00000145933
Ensembl peptide - ENSMUSP00000145908
Ensembl peptide - ENSMUSP00000145770
Ensembl peptide - ENSMUSP00000126458
Ensembl peptide - ENSMUSP00000116921
Ensembl peptide - ENSMUSP00000033135
Ensembl peptide - ENSMUSP00000101833
NCBI entrez gene - 21843     See in Manteia.
MGI - MGI:107913
RefSeq - XM_017322109
RefSeq - XM_017322108
RefSeq - XM_006507575
RefSeq - NM_009383
RefSeq - XM_006507571
RefSeq - XM_006507570
RefSeq - XM_006507572
RefSeq Peptide - NP_001334570
RefSeq Peptide - NP_001334569
RefSeq Peptide - NP_033409
swissprot - D3Z3Y4
swissprot - P70318
swissprot - Q545C1
swissprot - Q921W2
swissprot - A0A0U1RP00
swissprot - A0A0U1RPB0
swissprot - A0A0U1RPD3
swissprot - A0A0U1RPE1
swissprot - A0A0U1RPL4
swissprot - D6RGU1
Ensembl - ENSMUSG00000030846
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tial1ENSDARG00000009525Danio rerio
 TIA1ENSGALG00000009427Gallus gallus
 TIAL1ENSG00000151923Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tia1 / P52912 / cytotoxic granule-associated RNA binding protein 1 / P31483* / TIA1 cytotoxic granule associated RNA binding protein*ENSMUSG0000007133774
Rbm42 / Q91V81 / RNA-binding protein 42 / Q9BTD8* / RNA binding motif protein 42*ENSMUSG0000003673318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR003954  RNA recognition motif domain, eukaryote
 IPR034492  TIAR, RNA recognition motif 1
 IPR034494  TIAR, RNA recognition motif 2
 IPR034496  TIAR, RNA recognition motif 3
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0017145 stem cell division IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IDA


Pathways (from Reactome)
Pathway description
FGFR2 alternative splicing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0001128 ovary hyperplasia "increased cell number in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dstncorn1-2J/Dstncorn1-2J
Genetic Background: C57BL/6JSmn-Dstncorn1-2J/J

Allelic Composition: Tial1tm1Mst/Tial1tm1Mst
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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