ENSMUSG00000072235


Mus musculus

Features
Gene ID: ENSMUSG00000072235
  
Biological name :Tuba1a
  
Synonyms : P68369 / Tuba1a / tubulin, alpha 1A
  
Possible biological names infered from orthology : Q71U36
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 98949837
Gene end: 98953703
  
Corresponding Affymetrix probe sets: 10426650 (MoGene1.0st)   10432398 (MoGene1.0st)   10432404 (MoGene1.0st)   10587780 (MoGene1.0st)   1418884_x_at (Mouse Genome 430 2.0 Array)   1433584_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094778
NCBI entrez gene - 22142     See in Manteia.
MGI - MGI:98869
RefSeq - NM_011653
RefSeq Peptide - NP_035783
swissprot - P68369
Ensembl - ENSMUSG00000072235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TUBA1AENSGALG00000037953Gallus gallus
 Q71U36ENSG00000167552Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P05213 / Tuba1b / tubulin, alpha 1B / P68363*ENSMUSG00000023004100
Tuba3b / P05214 / tubulin, alpha 3B / TUBA3D* / Q13748* / Q6PEY2* / TUBA3E* / tubulin alpha 3d* / tubulin alpha 3e*ENSMUSG0000006733898
P68373 / Tuba1c / tubulin, alpha 1CENSMUSG0000004309198
P05214 / Tuba3a / tubulin, alpha 3A / Q13748* / TUBA3C* / tubulin alpha 3c*ENSMUSG0000006770298
P68368 / Tuba4a / tubulin, alpha 4A / P68366*ENSMUSG0000002620296
AC161165.4 / Q9BQE3* / TUBA1C* / tubulin alpha 1c*ENSMUSG0000011635859


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002452  Alpha tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007017 microtubule-based process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Hedgehog off state
Cilium Assembly
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
Hedgehog on state
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Tuba1aRgsc1736/Tuba1a+
Genetic Background: C3.B6-Tuba1aRgsc1736

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Tuba1aRgsc1736/Tuba1a+
Genetic Background: C3.B6-Tuba1aRgsc1736

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Tuba1aRgsc1736/Tuba1a+
Genetic Background: C3.B6-Tuba1aRgsc1736

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Tuba1aRgsc1736/Tuba1a+
Genetic Background: C3.B6-Tuba1aRgsc1736

 MP:0004631 abnormal auditory cortex morphology "any structural abnormality in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body, a thalamic cell group receiving auditory input from the cochlear nuclei in the rhombencephalon and is responsible for processing of auditory (sound) information" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tuba1aRgsc1736/Tuba1a+
Genetic Background: C3.B6-Tuba1aRgsc1736

 MP:0008284 abnormal hippocampus pyramidal cell layer 
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tuba1aRgsc1736/Tuba1a+
Genetic Background: C3.B6-Tuba1aRgsc1736

 MP:0009971 decreased hippocampus pyramidal cell number "decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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